Results 121 to 130 of about 5,744,523 (270)

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

Advanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai, Weikai Sun, Yuxuan Zhao, Daqian Sun, Ting Meng, Yafei Qi, Fengyang Jiang, Jintang Sun, Zhiliang Gao, Dexin Yu   +9 more
wiley   +1 more source

Framework for sustainable urban development of historical and cultural cities based on outstanding universal values

Humanities & Social Sciences Communications
Boosting heritage conservation alongside adaptation to overwhelming urbanisation and global tourism expansion presents a dual imperative for historical and cultural cities.
Xiaoting Ma, Nangkula Utaberta, Nadzirah Zainordin   +2 more
doaj   +1 more source

BCC presents 1984-85 cultural arts series

, 2010
Fall Semester posting of the Cultural Arts Series; Spring Semester posting of the Cultural Arts Series.Various events posted for the Black Cultural Center’s Cultural Arts Series of 1984-85.Photos of Phyllis Hyman and Alvin Poussaint included along with a
Purdue University. Black Cultural Center;
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Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Sotojiro Kitigawa interviewed by Rosemary Miles and Ian Fraser

, 1992
In this interview recorded on June 7, 1992, Sotojiro Kitigawa provides his recollections of various families members of the Japanese Canadian community in Kaslo during the war.

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Interview with Jock Gilmour

, 1979
Audio recording and transcript of Jock Gilmour's 1979 interview with Myrtle Bergren for the Coal Tyee History Project. Gilmour discusses both his own and his father's involvement in the Vancouver Island coal mining industry. He goes into detail about his
Gilmour, John
core   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

DSM-5® Handbook on the Cultural Formulation Interview [PDF]

American Journal of Psychiatry, 2016
Adia Kelly Cobb, Andres J. Pumariega
openaire   +2 more sources

Project 'Late gevolgen van Sobibor'

, 2012
Constance (Pim) Combrink-van Huizen is in Velsen geboren. In 1939 nadat haar ouders gescheiden zijn verhuist Constance met haar Joodse moeder en haar vierenhalf jaar oudere zus naar Huizen.
Selma Leydesdorff (copyright on interview), Universiteit van Amsterdam - Fac. Geesteswetenschappen, Selma Leydesdorff (copyright on interview)), Universiteit van Amsterdam - Fac. Geesteswetenschappen, Mirjam Huffener (project manager), Stichting Sobibor, Selma Leydesdorff (copyright on interview), Universiteit van Amsterdam - Fac. Geesteswetenschappen   +3 more
core   +1 more source