Results 71 to 80 of about 261,679 (272)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The politics, policies and progress of basic education in Sri Lanka [PDF]

, 2010
Sri Lanka is hailed internationally for her achievements in literacy, educational enrolment and equality of educational opportunity. However, progress has not been straightforward due to the complex interactions between politics, policy formulation, and ...
Little, Angela W
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

The European Union’s Multi-Level Cultural Diplomacy vis-à-vis the United States of America. Working Paper Series W-2018/7 [PDF]

, 2018
This paper examines how, to what extent and why the EU engages in cultural diplomacy vis-à-vis the US. While providing an empirical review of and conceptual reflection on the current state of the EU’s (including key member states’) efforts at employing ...
Schunz, Simon, Trobbiani, Riccardo
core  

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source

Culturally diverse families of young children with ASD in Sweden: Parental explanatory models.

PLoS ONE, 2020
BackgroundResearch suggests that families' knowledge and cultural perceptions of autism spectrum disorder (ASD), and beliefs about its etiology and prognosis, can affect parents' recognition of the first signs of autism in their children and influence ...
Rano Zakirova-Engstrand, Tatja Hirvikoski, Mara Westling Allodi, Lise Roll-Pettersson   +3 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Elite opinion and foreign policy in post-communist Russia [PDF]

, 2007
Russian elite opinion on matters of foreign policy may be classified as ‘Liberal Westerniser’, ‘Pragmatic Nationalist’ and ‘Fundamentalist Nationalist’, terms that reflect longstanding debates about the country’s relationship with the outside world.
Allison R., Almond G. A., Arbatov A., Arbatova N., Baker P., Batchikov S., Belkovsky S., Chubais A., Chubar'yan A., Delyagin M., Delyagin M., Dugin A., Dugin A., Dugin A., Dugin A., Dugin A., Dugin A., Dugin A., Dzyaloshinsky I., Frolov V., Glaz'ev S., Gorbachev M., Holsti O. R., Illarionov S. I., Inozemtsev V., Inozemtsev V., Inozemtsev V., Ishchuk A., Karaganov S., Karaganov S., Karaganov S., Karaganov S., Karaganov S., Kosachev K., Kosachev K., Kosachev K., Kosachev K., Kosachev K., Kosachev K., Krivitsky Y., Krivitsky Y., Kugushev S., Kvitsinsky Y., Kvitsinsky Y., Kvitsinsky Y., Light M., Luzhkov Y., Margelov M., Margelov M., Margelov M., Medvedeva I. Y., Migranyan A., Migranyan A., Miller W. L., Narochnitskaya N., Orlov B., Orlov D., Oznobishchev S., Polyannikov T., Primakov Y., Putin V., Rogozin D., Ryabov A., Schneider E., Sergunin A. A., Shevtsova L., Stephen White, Trenin D., Trenin D., Trenin D., Trenin D., Voronov K., Zyuganov G., Zyuganov G., Zyuganov G.   +74 more
core   +1 more source