Results 101 to 110 of about 951,967 (336)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
BMC Medical EducationBackground Feedback is an important part of learning, however, it often does not have the desired effect. Much work has been done exploring students’ engagement with feedback and factors which may impact engagement.
Alison Lupton-Smith +2 more
doaj +1 more source
Using cultural-historical activity to study clinical reasoning in context [PDF]
, 2008 The aim of this paper is to describe sources of conflict and congruence in critical areas of practice with caregivers of persons with dementia, using cultural-historical activity theory as an analytic framework.
Toth-Cohen, Susan
core +1 more source
Spatial relations, histories from below and the makings of agency: Reflections on The Making of the English Working Class at 50 [PDF]
, 2015 In this paper we propose a conversation between work in labour history and labour geography, in part centring on the formative contribution of E.P. Thompson.
Featherstone, David, Griffin, Paul
core +3 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
MatriksMovie: Building The Nation Character Through Movie-Based Realistic Mathematics Education [PDF]
, 2011 The root of RME is Hans Freudenthal’s interpretations, mathematics as human activity and mathematics must be connected to reality. This study developed a mathematics teaching and learning model that includes the characteristics of RME packaged in ...
Adi , Nur Cahyono
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The Researcher's Role: An Ethical Dimension
Outlines, 2006 Different paradigms or perspectives function as the point of departure and framework for research. In this article ethical issues in the positivist and constructivist paradigms are presented.
May Britt Postholm, Janne Madsen
doaj
Культурно-историческая психология, 2017 With reference to the Presentation of the colleague Lucisano of the Sapienza University, the author stresses the still great meaning of the KIP by Vygotskij for a correct understanding of today’s needs for education and instruction in Europe.
Veggetti M.S.,
doaj +1 more source