Results 81 to 90 of about 7,153,876 (295)
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Primary research on the bronze technology of Lower Xiajiadian Culture in northeastern China
Heritage Science, 2019 The site of Habaqila is located in the area between Inner Mongolia and Liaoning provinces and dated to the 13th–11th centuries BC. It was identified as a metal production workshop of the Lower Xiajiadian Culture and revealed abundant metallurgical ...
Chenyuan Li +4 more
doaj +1 more source
The Taming of Psidium guajava: Natural and Cultural History of a Neotropical Fruit. [PDF]
Front Plant Sci, 2021 Arévalo-Marín E +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Characterization and identification of an archaeological “lacquer” pipe
Heritage ScienceA pipe with red coating on the surface was excavated from an archaeological site in Sweden, which is supposed to be a lacquer ware imported from China due to the admiration and pursue of lacquer wares from Asia by Europeans during sixteenth to eighteenth
Yazhen Huang +4 more
doaj +1 more source
The Long-Term Reuse of Text in the Finnish Press, 1771–1920
Digital Humanities in the Nordic and Baltic Countries Publications, 2019 This paper is based on the study of text reuse in the Finnish press from 1771–1920. In the Computational History and the Transformation of Public Discourse in Finland (COMHIS) project, we found 61 million occurrences of similarity, which formed 13.8 ...
Hannu Salmi +3 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Digital OBL, AI and Robotics for inclusive heritage education experiences
Ubiquity ProceedingsObject-Based Learning (OBL) is a pedagogical methodology that fosters interactive and immersive engagement with cultural heritage, while promoting key transversal skills: Creativity, Communication, Collaboration, and Critical Thinking (4Cs).
Antonella Poce +6 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source