Results 81 to 90 of about 2,058,141 (351)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

TURKISH IDENTITY. ETHNIC AND CULTURAL CHARACTERISTICS AND IDENTITY FORMATION

open access: yesStudia Universitatis Babeş-Bolyai. Studia Europaea
Turkish identity has two fundamental pillars: ethnic identity and cultural identity. These two pillars were formed and later consolidated on a historical route of going from the presocietal ethnic groups to the tribal organisation and then to a ...
Irina-Maria COSMA
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Negotiating the in-between : how two foreigners living in rural Japan narrated changes in their identities : a thesis presented in partial fulfilment of the requirements for the degree of Masters in Education (Guidance Studies), Massey University, Palmerston North, New Zealand [PDF]

open access: yes, 2009
This thesis used narrative inquiry to find out how two foreigners, who had resided in rural Japan for a long period of time, narrated reflectively how they had changed as a result of their cross-cultural transitions. This thesis came about through my own
Lankshear, Andrew
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

"Culture of Identity" and "Identity of Culture"

open access: yesPhilological studies (Skopje), 2010
In this paper I am interested in special relation between individual aspect of culture which is connected with identity, forms and narrative discourses that establishes it and the issue of common culture, reference to social aspects of culture. Problems between individual identity and common culture are complex and interlaced ; what is more, their ...
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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