Results 101 to 110 of about 779,176 (289)

Research methodology in montanistic tourism [PDF]

open access: yes, 2017
Research methodology in montanistic tourism involves the archival research and study of special literature, surface and underground field survey, the analysis of findings of rock fragments, mineral composition, traces of metallurgical processes ...
Schejbal, Ctirad
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

The Place and Face of the Stranger in Levinas

open access: yesReligions, 2019
This essay addresses the topic of place, more specifically it raises the question how and why place is essential for defining the strangeness of the other person. In Levinas’ philosophy the Other as stranger is the one whom I welcome to my home and
Jolanta Saldukaitytė
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Low-tech serious games in higher education: bridging the digital divide and enhancing student thinking and performance

open access: yesHumanities & Social Sciences Communications
Serious games in education are often tied to digital learning environments, which require complex gamified content and systems to enhance students’ motivation.
Chong-Wen Chen
doaj   +1 more source

Research on the Digital Preservation of Architectural Heritage Based on Virtual Reality Technology

open access: yesBuildings
As a representative of the scientific and technological achievements of the new era, the overall development of virtual reality (VR) technology is becoming increasingly refined, which provides new development ideas and technical support in the field of ...
Haohua Zheng   +4 more
doaj   +1 more source

Reappraising the Visionary Work of Arata Isozaki: Six Decades and Four Phases

open access: yesArts, 2017
This article analyses the work and presents a portrait of Japanese architect Arata Isozaki. His designs and buildings span six decades and it is suggested that these can be categorised into four distinctively different phases. As a former collaborator of
Steffen Lehmann
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy