Results 71 to 80 of about 779,176 (289)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
The relationship between communication and education through the creative personality of the teacher
Creativity Studies, 2019 The article focuses on the relationships of communication and educational processes, creativity aspects in the context of higher education. A creative personality of the teacher determines how smooth and efficient these relationships are.
Vida Navickienė +3 more
doaj +1 more source
CULTURAL-PRODUCTS INDUSTRIES AND URBAN ECONOMIC DEVELOPMENT: PROSPECTS FOR GROWTH AND MARKET CONTESTATION IN GLOBAL CONTEXT [PDF]
The paper opens with a brief definition of the cultural economy. A first generation of local economic development policy approaches based on place-marketing and associated initiatives is described.
Allen J Scott
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Self-discontinuity in behavioral addictions: A psychodynamic framework
Addictive Behaviors ReportsModels based on substance use criteria have been employed to classify maladaptive engagement in various everyday activities as genuine addictions. However, symptom-based models have potential limitations, which includes in some cases reduced clinical ...
Gianluca Santoro +3 more
doaj +1 more source
Why do creative industries cluster? An analysis of the determinants of clustering of creative industries [PDF]
Creative industries tend to concentrate mainly around large- and medium-sized cities, forming creative local production systems. The text analyses the forces behind clustering of creative industries to provide the first empirical explanation of the ...
Francesco Capone +2 more
core
Cultural industries, nation and staten in the work of Renato Ortiz: a view from inside the Anglosphere [PDF]
, 2018 This short essay reflects on Renato Ortiz’s work and its reception in the Anglosphere. It then discusses the author’s meeting with Ortiz in Scotland during a European-Latin American ‘encounter’ set up to discuss cultural identity and communication ...
Schlesinger, Philip
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Innate and Cultural Spatial Time: A Developmental Perspective
Frontiers in Human Neuroscience, 2017 We reviewed literature to understand when a spatial map for time is available in the brain. We carefully defined the concepts of metrical map of time and of conceptual representation of time as the mental time line (MTL) in order to formulate our ...
Barbara Magnani, Alessandro Musetti
doaj +1 more source
Benchmarking and understanding London’s Cultural and Creative Industries [PDF]
This paper describes the Greater London Authority’s evidence base for its work on the creative and cultural industries. Its main purpose is to show that th9is evidence base is viable, robust, and useful.
Freeman, Alan
core +1 more source