Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Value of the Dead: The Commodification of Corpses in Western Culture [PDF]
, 2018 Since the 19th century, the deceased human body and its parts have been increasingly dehumanized, objectified, and commodified in Western culture. Thus, in a relatively short period of time, the corpse became, and continues to be, a highly valuable ...
Wallace, Charles Z.
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Retracted: Static and Dynamic Demonstration of the Ecological Level of Ethnic Cultural Industries Based on the Internet of Things and Environmental Responsibility. [PDF]
J Environ Public Health, 2023 Environmental And Public Health JO.
europepmc +1 more source
Singing all the Way to the Bank: The Case for Economic Development through Music in Cape Verde [PDF]
There has been an increasing awareness within the developed world that the cultural industries may play an important role in economic development. The fact that most of the commercial cultural industries have relatively low distribution costs, and that ...
Samer Saab
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Conjunctions of resilience and the Covid-19 crisis of the creative cultural industries. [PDF]
Int J Cult Stud, 2022 Yue A.
europepmc +1 more source
The Cultural Economy of Paris [PDF]
The cultural economy is defined in terms of a set of sectors ranging from certain traditional artisanal industries like clothing or jewelry on the one side, to newer media industries like sound recording or television program production on the other.
Allen J. Scott
core
'Thinking of Spain in a flat way:' visiting Spain and Spanish cultural heritage through contemporary Japanese anime [PDF]
, 2017 This article contextualizes the representation of Spain and Spanish culture among Japanese cultural producers, particularly through the production of Japanese commercial animation (commonly named anime).
Hernandez-Perez, Manuel
core +1 more source
The politics of journalistic creativity: expressiveness, authenticity and de-authorization [PDF]
, 2012 This article begins with the assertion that creativity in journalism has moved from being a matter of guile and ingenuity to being about expressiveness, and that this reflects a broader cultural shift from professional expertise to the authenticity of ...
Markham, Tim
core +1 more source