Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Between plumbers and mushrooms. The cinema adaptation of the classic videogame Super Mario Bros
Doxa ComunicaciónIn this article, cinema and video games converge with the aim of analyzing the audiovisual treatment of the characters who acquire an important role in the film Super Mario Bros: The Movie (Horvarth and Jelenic, 2023) and the transformations raised with
María Nieves Corral Rey +1 more
doaj +1 more source
Innovation and Integration Development of the Cultural Industry Based on Mapping Knowledge Domains. [PDF]
Comput Intell Neurosci, 2022 Lian J, Liang D.
europepmc +1 more source
Rethinking International Compensation: From Expatriate and National Cultures to Strategic Flexibility [PDF]
, 1997 [Excerpt] We are on the verge of a worldwide restructuring of compensation and reward systems. Even long established, seemingly carved-in-granite cultural norms, such as lifetime employment in Japan and industry-wide bargaining in Germany, are weakening ...
Bloom, Matthew C. +1 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Modified 2-tuple Linguistic Neutrosophic Hybrid GRA Framework for Comprehensive Strength Evaluation for High-Quality Development in the Cultural Industry [PDF]
Neutrosophic Sets and SystemsThe evaluation of comprehensive strength for the high-quality development of the cultural industry is a systematic assessment of the overall performance of the cultural sector across multiple dimensions.
Xiuhuan Feng +3 more
doaj +1 more source
Cultural industry development from entrepreneurship under the background of rural revitalization strategy. [PDF]
Front Psychol, 2022 Gao J.
europepmc +1 more source
The Impact of Geographic and Cultural Dispersion on Information Opacity [PDF]
, 2017 This paper investigates the influences of intrafirm geographic and cultural dispersion, the distance between the location of a firm’s investments and its headquarters, on the firm’s information environment. Specifically, using a sample of publicly traded
Cashman, George D. +3 more
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source