Results 81 to 90 of about 6,600,071 (309)

The recognition problem in collective optimal experience: the identity of generation and recognition as a structural event

open access: yesFrontiers in Psychology
The recognition of collective optimal experience remains structurally unresolved in psychology. Existing frameworks—from group flow to collective effervescence—have extended optimal experience to the collective level, yet they have generally treated ...
Isabella Langwei   +2 more
doaj   +1 more source

S'Esclop. Quadern cultural 2008, no. 39 [PDF]

open access: yes, 2008
not ...
Esclop Associació Cultural
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

A Systematic Review of Contemporary Challenges and Debates on Chinese Food Security: Integrating Priorities, Trade-Offs, and Policy Pathways

open access: yesFoods
Although food security has been a long-standing focus of research and policy in China, significant gaps remain in synthesizing evolving debates across multiple disciplines such as agriculture, economics, environmental science, and politics.
Rong Zeng   +4 more
doaj   +1 more source

S'Esclop. Quadern cultural 2009, no. 45 [PDF]

open access: yes, 2009
not ...
Esclop Associació Cultural
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

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