Results 61 to 70 of about 6,600,071 (309)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Le paysage télévisuel espagnol actuel : un chaos régénérateur ?
Cahiers de Civilisation Espagnole Contemporaine, 2011 El sistema televisivo español es uno de las más complejos de Europa. Su estructura comprende cuatro niveles diferentes, correspondientes a los tipos de público y de mercado a los que ha dado lugar el desmantelamiento del aparato audiovisual y la cultura ...
Jean-Stéphane Duran Froix
doaj +1 more source
Assignments - A Cultural Awakening at the BCC
, 2013 6th Annual Cultural Arts Festival commemorating the 10th anniversary of the BCC.Front page cover of the program containing a list of activities scheduled for the commemorative celebration.No ...
Purdue University Black Cultural Center
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Índices de impacto cultural: antecedentes, metodología y resultados
, 2014 El resultado que se registra en el presente documento es un hallazgo metodológico para la definición de una batería de indicadores de efecto e impacto cultural y para la construcción de índices de impacto cultural.
Banco de la República (Bogotá). Subgerencia Cultural
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
New energy vehicle battery state of charge prediction based on XGBoost algorithm and RF fusion
Energy InformaticsAs the most important component of new energy electric vehicles, lithium-ion batteries may suffer irreversible damage to the battery due to an abnormal state of charge. Nevertheless, the extant research on charge prediction predominantly employs a single
Changyou Lei
doaj +1 more source