Results 71 to 80 of about 6,848,042 (258)

Quantitative Evaluation of Digital Economy Policies in the Tourism Industry Using the TF-IDF and PMC Index Model

IEEE Access
With the acceleration of globalization, the development of the tourism industry increasingly relies on cross-border collaboration, and the digital economy can provide new opportunities for the tourism industry and promote the global application of new ...
Yu Xia
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Short-video engagement, health-related behaviors, and mental well-being: Evidence from a longitudinal study of Chinese youth

Acta Psychologica
The rapid growth of short-form video platforms presents both potential public health considerations and new avenues for social engagement, yet longitudinal evidence on how different patterns of short video use are linked to youth mental health remains ...
Dong Zhou, Li-Min Lin
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Índices de impacto cultural: antecedentes, metodología y resultados

, 2014
El resultado que se registra en el presente documento es un hallazgo metodológico para la definición de una batería de indicadores de efecto e impacto cultural y para la construcción de índices de impacto cultural.
Banco de la República (Bogotá). Subgerencia Cultural
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

New energy vehicle battery state of charge prediction based on XGBoost algorithm and RF fusion

Energy Informatics
As the most important component of new energy electric vehicles, lithium-ion batteries may suffer irreversible damage to the battery due to an abnormal state of charge. Nevertheless, the extant research on charge prediction predominantly employs a single
Changyou Lei
doaj   +1 more source

Metabolic Trade-Off Between Radical Scavenging Chemotype, Starch Accumulation, and Volatile Aroma Profile in Early- and Late-Maturing Apple Cultivars: Implications for Breeding and Postharvest Quality

Horticulturae
Apple maturation involves profound metabolic reconfiguration, yet systematic trade-offs among bioactive, primary, and volatile metabolites remain unclear, particularly under highland cultivation.
Mingzheng Duan, Tingfen Lu, Xingpeng Wang, Congjing Chen, Yuanqiao Li, Xue Wang, Ahua Bo, Xiande Duan, Muhammad Junaid Rao, Rongjing Cai   +9 more
doaj   +1 more source

Le paysage télévisuel espagnol actuel : un chaos régénérateur ?

Cahiers de Civilisation Espagnole Contemporaine, 2011
El sistema televisivo español es uno de las más complejos de Europa. Su estructura comprende cuatro niveles diferentes, correspondientes a los tipos de público y de mercado a los que ha dado lugar el desmantelamiento del aparato audiovisual y la cultura ...
Jean-Stéphane Duran Froix
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source