Results 71 to 80 of about 6,600,071 (309)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

S'Esclop. Quadern cultural 2010, no. 52 [PDF]

, 2010
not ...
Esclop Associació Cultural
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Correction: Gargalis et al. A Comparative Investigation of Duplex and Super Duplex Stainless Steels Processed through Laser Powder Bed Fusion. Metals 2023, 13, 1897

Metals
In the original publication [...]
Leonidas Gargalis, Leonidas Karavias, Joachim S. Graff, Spyros Diplas, Elias P. Koumoulos, Evangelia K. Karaxi   +5 more
doaj   +1 more source

Bond funded cultural facility projects

, 2007
Ed. 3.0.; Title from PDF cover (viewed on Feb. 13, 2008).; "January 2007."; Includes index.; Harvested from the web on 2/14/08Ed.
Ohio Cultural Facilities Commission.
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Inverse scheduling method for aircraft flat-tail assembly production based on improved genetic algorithm

Scientific Reports
The manufacturing process of the aircraft flat-tail assembly is complex and discrete. It typically involves manual assembly at fixed stations with variable shift teams.
Tengda Li, Min Hua, Junliang Wang, Wei Qin   +3 more
doaj   +1 more source

Real-time sensor networks based on genetic algorithms application in the analysis of innovative data in cultural industry management

Measurement: Sensors
Against the backdrop of sustained economic development and steady improvement of China's overall national strength, the cultural industry is in a good stage of development, but it also faces problems such as data complexity and difficulty in organizing ...
Baohui Zhang, Zaixi Yang, Jinqing Zhang, Qingqing Xu   +3 more
doaj   +1 more source

Repenser l’héritage critique des revues

Tracés, 2018
This paper starts from the ambivalent relation that links researchers and intellectual journals during the twentieth and the twenty-first centuries. After questioning the definition of these journals as critical media of knowledge, as specific supports ...
Thomas Franck, Caroline Glorie, Alain Loute   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source