Results 51 to 60 of about 6,848,042 (258)

Tourism development and ecological impact assessment based on fuzzy TOPSIS method

Discover Artificial Intelligence
The growth of tourism is essential for economic development and the dissemination of cultural ideas; however, it also creates significant environmental problems that necessitate thorough remedial action.
Baohui Zhang, Huijun Xiao, Jinqing Zhang
doaj   +1 more source

The influence factors of tour guides' professional identity and professional decision before and after the COVID-19 pandemic

Heliyon
The COVID-19 pandemic has significantly impacted the tourism sector, particularly tour guides (TGs), affecting their professional identity (TGPI) and intentions to return to work.
Wenwen Hu, Qing Yuan, Yaxi Wang, Nan Chen   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Date estimation of fabrication and repair of Color garments encouragement banner

Fashion and Textiles
The Color Garments Encouragement Banner was designated a Korean Heritage in 2014 to recognize it as the most significant object of the color garments encouragement campaign.
Seonghee Pak, Boyeon An, Changsang Yun
doaj   +1 more source

Optimized CNN-based facial analysis for depression detection: Managing mental disorder in education

Brain Research Bulletin
Major Depressive Disorder (MDD) is frequently under-identified in educational contexts, including arts and design programs, where limited clinical resources and privacy concerns restrict routine screening.
Mengqiu Wang, Yanxia Wu, Khosro Rezaee, M. Khosravi   +3 more
doaj   +1 more source

The whole genome assembly and evolution analyze of carmine radish (Raphanus sativus L.) Mitochondrion

Mitochondrial DNA. Part B. Resources, 2020
Carmine radish, which contained a high natural red pigment (red radish pigment), was peculiar produced in Fuling, Chongqing City. Here, the complete nucleotide sequences of the mitochondrial (mt) genome of carmine radish (Raphanus sativus L.) have been ...
Hua Peng, Jian Gao
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Evaluate the web-based tourism management by using the fuzzy expert system

Discover Internet of Things
Web-based tourism systems improve travel planning and destination discovery. However, they often face challenges in handling ambiguous user preferences and dynamic factors such as season, budget, and travel duration, reducing recommendation accuracy ...
Baohui Zhang, Qingqing Xu, Xianlin Yao, Jinqing Zhang   +3 more
doaj   +1 more source