Results 31 to 40 of about 73,436 (247)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Tracing Cultural Landscape Values of Children with Participatory Geographic Information System

European Countryside, 2017
The cultural landscape value categories found from the workshop evaluation describe the character of the cultural landscape of children: living, learning and moving in the network of places between home and the world outside based on the local and family
Puolamäki Laura
doaj   +1 more source

A long-term influence of anthropogenic alkalization on molluscs biodiversity in an area affected by cement industry, Świętokrzyskie Mountains, South-Central Poland

Archives of Environmental Protection, 2015
The presented paper reports data from malacological and pedological studies carried out at sites representing diverse biotopes (beech wood, coniferous forest, and meadow) located 2 km away from the Dyckerhoff Cement Plant in Sitkówka-Nowiny in 1992 and ...
Barga-Więcławska Jadwiga Anna, Świercz Anna   +1 more
doaj   +1 more source

How has the landscape changed? Landscape transformation analysis of Ogrodzieniec-Podzamcze (POLAND) using landgraphy and landscape stratigraphy methods.

Landscape Online, 2023
This article presents a combination of landscape biography and stratigraphy as a method for the visualisation of historical landscape change. The main goal was to analyse the evolution of the cultural landscape of part of the Ogrodzieniec municipality –
Urszula Myga-Piątek, Anna Żemła-Siesicka   +1 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

The cultural landscape: From conservation to planning concept [PDF]

Glasnik Šumarskog Fakulteta: Univerzitet u Beogradu, 2016
The interpretation of the concept of cultural landscape, as well as the interpretation of the general concept of landscape, depends on the context in which the process takes place.
Vasilјević Nevena, Radić Boris
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Research on Leased Space of Urban Villages in Large Cities Based on Fuzzy Kano Model Evaluation and Building Performance Simulation: A Case Study of Laojuntang Village, Chaoyang District, Beijing

Buildings
China is in the transition period of urbanization, and the imbalance of land use generated during the original rapid development of megacities still exists, resulting in the preservation of a large number of urban villages in the peripheral areas of ...
Liuchao Wei, Wei Duan, Siqiao Dong
doaj   +1 more source