Results 51 to 60 of about 4,676,992 (300)
BuildingsChina is in the transition period of urbanization, and the imbalance of land use generated during the original rapid development of megacities still exists, resulting in the preservation of a large number of urban villages in the peripheral areas of ...
Liuchao Wei, Wei Duan, Siqiao Dong
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Examining Cultural Drifts in Artworks through History and Development: Cultural Comparisons between Japanese and Western Landscape Paintings and Drawings. [PDF]
, 2014 Nand, K., Masuda, T., Senzaki, S., & Ishii, K. (2014). Examining cultural drifts in artworks through development and history: Cultural comparisons between Japanese and Western landscape paintings and drawings.
Masuda, Takahiko
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Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Machine learning approaches to dietary classification from dental microtexture in primates
Scientific ReportsDental microwear texture (DMT) analysis is a critical proxy for reconstructing the diets of extant and extinct mammals. While craniodental morphology reflects selective pressures across evolutionary timescales, microwear captures localized, short-term ...
Ferran Estebaranz-Sánchez +5 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2013 Implementation of the European Landscape Convention requires new tools that link ecological, social and cultural dimensions in practical planning. Here, we propose connectivity as a conceptual tool to include different dimensions into landscape and ...
Mikusinski, Grzegorz, +4 more
core +2 more sources
Forest drainage in the Hunsrück-Hochwald National Park - an integrative approach
Landscape OnlineThe management of drained wetlands has become a key focus in the implementation of climate change adaptation measures in recent years, particularly in forested areas.
Jörn Schultheiß, Werner Konold
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Preschoolers Learning with the Internet of Toys: From Toy-Based Edutainment to Transmedia Literacy
Seminar.net, 2018 The Internet of Toys (IoToys) as an emerging type of edutainment presents a new research area, especially in the context of learning. This study investigates four connected toys played with in the preschool context.
Katriina Heljakka, Pirita Ihamäki
doaj