Results 51 to 60 of about 1,037,703 (310)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Research on Leased Space of Urban Villages in Large Cities Based on Fuzzy Kano Model Evaluation and Building Performance Simulation: A Case Study of Laojuntang Village, Chaoyang District, Beijing

Buildings
China is in the transition period of urbanization, and the imbalance of land use generated during the original rapid development of megacities still exists, resulting in the preservation of a large number of urban villages in the peripheral areas of ...
Liuchao Wei, Wei Duan, Siqiao Dong
doaj   +1 more source

The spatial narrative of Island Cultural Landscapes: A Case of Lakshadweep Group of Islands, India

Proceedings of the International Conference of Contemporary Affairs in Architecture and Urbanism-ICCAUA, 2023
Islands are known for their distinctive landscapes, which have greatly influenced the cultures and societies of the people who have lived there. Islands are unique, geographically isolated places with specific physical and cultural traits that are ...
Safiya MD, Ram Sateesh Pasupuleti
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Evaluating the adaptive capacity of cultural landscapes to climate change: Incorporating site-specific knowledge in National Park Service vulnerability assessments [PDF]

, 2020
Cultural landscapes are complex systems of natural and cultural resources that are affected by changes in climatic and non-climatic factors. The National Park Service, Pacific West Region, has developed a vulnerability assessment (VA) model for ...
Germano, Vida, Johnson, Christopher E.
core  

Framing the relationship between people and nature in the context of European conservation [PDF]

, 2015
A key controversy in conservation is the framing of the relationship between people and nature. The extent to which the realms of nature and human culture are viewed as separate (dualistic view) or integrated is often discussed in the social sciences. To
Agnoletti, Apollonio, Bauer, Bekoff, Bendrey, Birks, Blanco, Boitani, Castree, Chapron, Cronon, Descola, Descola, Descola, Donlan, Ellen, García, Ghosal, Gunther, Halada, Haraway, Hobbs, Hodder, Ingold, Isselstein, Jones, Kerley, Kirby, Knight, Latour, Latour, Linnartz, Linnell, Liu, Lorimer, López-Bao, Mace, Maffi, Marris, Martin, Marvier, Mattisson, Milton, Monbiot, Mysterud, Navarro, Ordiz, Phalan, Queiroz, Redpath, Robbins, Rubenstein, Schwartz, Selva, Terborgh, Treves, Tsiafouli, Vera, Vos, Watson   +59 more
core   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The cultural landscape: From conservation to planning concept [PDF]

Glasnik Šumarskog Fakulteta: Univerzitet u Beogradu, 2016
The interpretation of the concept of cultural landscape, as well as the interpretation of the general concept of landscape, depends on the context in which the process takes place.
Vasilјević Nevena, Radić Boris
doaj   +1 more source

Landscape aesthetics: Assessing the general publics’ rural landscape preferences [PDF]

, 2011
working paperThe central aim of this study was to gain greater insights into the factors that affect individuals’ preferences for a variety of landscape settings.
Howley, Peter
core