Results 51 to 60 of about 72,601 (261)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cultural Landscape and Migration

Dhaulagiri Journal of Sociology and Anthropology, 2011
This paper focus on the way Nepalese migrants in Myanmar use features of the natural environment in their homeland in metaphoric constructions of a cultural landscape expressing ethnic identity.
Gunnar Haaland
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Evaluation and optimization of park cooling benefits based on cumulative impact and landscape pattern

Scientific Reports
City parks can cool the surrounding environment and mitigate the urban heat island (UHI) effect, considerable improving the city’s adaptability to climate.
Yao Xiong, Xinyu Xie, Yunfeng Yang
doaj   +1 more source

EXPERIENCE OF LOCAL ZONING OF CULTURAL LANDSCAPES OF THE NORTH CAUCASUS

Наука. Инновации. Технологии, 2022
This paper deals with the theoretical and methodological problems of cultural landscape regionalization mikrogeograficheskom level research. As an example, the traditional IP-toric cultural landscape Stavropol Turkmen, urban cultural landscape of the ...
Alexey Vladimirovitsh Lysenko, Daria Sergeevna Vodopyanova, Dmitry Sergeevitsh Azanov   +2 more
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Different, different but same? Recreational opportunities and user preferences of inner-city Urban Green Spaces in Hanover and Thessaloniki

Frontiers in Sustainable Cities
Studies on Urban Green Spaces (UGSs) often focus on quantity and/or proximity but lack qualitative assessment, which is particularly important in the case of cross-regional comparisons.
Karlotta Ingmann, Garyfallia Katsavounidou, Nora Mehnen   +2 more
doaj   +1 more source

A landscape of cultures

, 2022
A brief introduction on cultural aspects of landscape ...
openaire   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Cultural Landscape in World Heritage Conservation and Cultural Landscape Conservation Challenges in Asia

Built Heritage, 2018
UNESCO was the first United Nations agency to deal with landscapes at a global scale, notably through the World Heritage Convention. In 1992, Cultural Landscapes’ became a new category on the World Heritage List combining works of nature and of humankind:
Mechtild Rössler, Roland Chih-Hung Lin
doaj   +1 more source