Results 31 to 40 of about 4,676,992 (300)
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The Cultural Landscape Concept [PDF]
This article sets forth the importance of landscape in our society due to an ever growing environmental awareness, being a key concept for the understanding of territories people inhabit. A comprehensive view of landscape is postulated.
Luis Álvarez Munárriz
doaj +1 more source
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Climate Change Threats to Socio-cultural Landscape of Island Countries
The significant effects of climate change in countries around the world has motivated call for countries to be more proactive in addressing root causes rather than being merely reactive.
Idienumah, P., Fakuade, D.
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Nonlinear landscape and cultural response to sea-level rise [PDF]
Rising sea levels have been associated with human migration and behavioral shifts throughout prehistory, often with an emphasis on landscape submergence and consequent societal collapse.
Johns, C +87 more
core +2 more sources
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Two in vitro methods were tested to establish their potential to predict the metabolizable energy (ME) content of forage legumes: the Tilley and Terry (TT) method and the pepsin-cellulase method (CM). Different samples of white clover (Trifolium repens L.
Gierus Martin +5 more
doaj +1 more source
Small Cultural Forests: Landscape Role and Ecosystem Services in a Japanese Cultural Landscape
Small woods, linear tree formations, or scattered trees in agricultural areas are receiving increasing attention for their multifunctional role, especially if associated to cultural landscapes.
Francesco Piras +2 more
doaj +1 more source

