Results 71 to 80 of about 4,676,992 (300)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Evaluation and optimization of park cooling benefits based on cumulative impact and landscape pattern

open access: yesScientific Reports
City parks can cool the surrounding environment and mitigate the urban heat island (UHI) effect, considerable improving the city’s adaptability to climate.
Yao Xiong, Xinyu Xie, Yunfeng Yang
doaj   +1 more source

Landscape aesthetics: towards a better understanding of rural landscape preferences [PDF]

open access: yes
The central aim of this study was to gain greater insights into the factors that affect individuals’ preferences for a variety of landscape settings. To achieve this aim, this paper derived dependent variables (based on a factor analysis of respondents ...
Howley, Peter
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

EXPERIENCE OF LOCAL ZONING OF CULTURAL LANDSCAPES OF THE NORTH CAUCASUS

open access: yesНаука. Инновации. Технологии, 2022
This paper deals with the theoretical and methodological problems of cultural landscape regionalization mikrogeograficheskom level research. As an example, the traditional IP-toric cultural landscape Stavropol Turkmen, urban cultural landscape of the ...
Alexey Vladimirovitsh Lysenko   +2 more
doaj  

A landscape of cultures

open access: yes, 2022
A brief introduction on cultural aspects of landscape ...
openaire   +1 more source

The cultural landscape in the Krageholm area during the Bronze Age

open access: yes, 1991
A description of the cultural landscape in the Krageholm area, southern Sweden, during the Bronze ...
Olausson, Deborah,, Lund University.
core  

Landscape practice in the Middle East between local and global aspirations [PDF]

open access: yes, 2016
: In the Middle East today, there are strong tensions between global and local aspirations in landscape architectural projects. Modernism, introduced to major cities in the Middle East, led to design approaches that are detached from local context, some ...
Makhzoumi, Jala M.   +2 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Natura 2000 sites as a crucial part of nature conservation? An analysis of landscape development in selected areas of the Czech Republic

open access: yesMoravian Geographical Reports
The Natura 2000 network is the key tool for preserving biodiversity in the EU. However, such a system of territorial protection is under increasing anthropogenic pressure and sites with no national designation are managed rather insufficiently across ...
Janík Tomáš   +8 more
doaj   +1 more source

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