Results 71 to 80 of about 72,601 (261)

Model of interaction of geographic, cultural and sacral landscapes

open access: yesНеофилология, 2015
The interaction of geographical, cultural and sacred landscapes is considered. The concept “landscape” is analyzed and its interdisciplinary character is emphasized. It is proposed to divide the definition of phenomenon on the concept “theoretical models”
Nataliya Nikolaevna LAVRINOVA
doaj  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

open access: yesFEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima   +7 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Necrology: Professor P.R. Sharma (1950 – 2020)

open access: yesSpace and Culture, India, 2020
Rana P.B. Singh
doaj   +1 more source

Digital afterlives: Tracing the resurrection process of dead online cultures

open access: yesNordic Journal of Media Studies
In this article, we discuss the different dynamics of the resurrection process of “dead” online cultures and objects. We have previously defined four life phases of online objects (active, passive, zombie, haunting), and this article adds resurrection as
Sihvonen Lilli, Vaahensalo Elina
doaj   +1 more source

Empowering Adult Learning How AI Fuels Progress Across Disciplines and Professions

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article examines the evolving role of artificial intelligence (AI) as a transformative cognitive partner across educational and professional fields. It explores how AI shifts attention away from routine technical tasks and toward human‐centered skills such as critical thinking, ethical decision‐making, and professional judgment.
Rachel Wlodarsky
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

Landscape and Culture

open access: yesPolish Journal of Landscape Studies, 2019
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openaire   +2 more sources

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