Results 61 to 70 of about 150,522 (307)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The absence of absence: a (geographical hi)story of the landscape of Blackpool [PDF]
, 2008 Throughout the past decade contemporary human geography has seen a decisive move away from the structuralist analysis of the New Cultural era, to a more fluid, deconstructed and poststructuralist approach, perhaps best encapsulated within the ...
Shires, Kate
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Scientific ReportsCity parks can cool the surrounding environment and mitigate the urban heat island (UHI) effect, considerable improving the city’s adaptability to climate.
Yao Xiong, Xinyu Xie, Yunfeng Yang
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Frontiers in Sustainable CitiesStudies on Urban Green Spaces (UGSs) often focus on quantity and/or proximity but lack qualitative assessment, which is particularly important in the case of cross-regional comparisons.
Karlotta Ingmann +2 more
doaj +1 more source
Built Heritage, 2018 UNESCO was the first United Nations agency to deal with landscapes at a global scale, notably through the World Heritage Convention. In 1992, Cultural Landscapes’ became a new category on the World Heritage List combining works of nature and of humankind:
Mechtild Rössler, Roland Chih-Hung Lin
doaj +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
The cultural landscape in the Krageholm area during the Bronze Age
, 1991 A description of the cultural landscape in the Krageholm area, southern Sweden, during the Bronze ...
Olausson, Deborah,, Lund University.
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The Shifting Sands: a Study of the Maritime Cultural Landscape of New Bern, North Caorlina
, 2023 The history of North Carolina’s ongoing settlement and the process of developing a future is a fascinating part of the state’s rich history. And New Bern, North Carolina had a strong maritime tradition and a unique history to study.
NC DOCKS at East Carolina University +1 more
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