Results 61 to 70 of about 4,676,992 (300)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Shifting Sands: a Study of the Maritime Cultural Landscape of New Bern, North Caorlina
, 2023 The history of North Carolina’s ongoing settlement and the process of developing a future is a fascinating part of the state’s rich history. And New Bern, North Carolina had a strong maritime tradition and a unique history to study.
NC DOCKS at East Carolina University +1 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Landscape Biographies explores the long and complex histories of landscapes from personal and social perspectives. As an essential part of human life-worlds, landscapes have the potential to absorb something of people's lives, works, and thoughts.
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Cultural Landscape and Migration
Dhaulagiri Journal of Sociology and Anthropology, 2011 This paper focus on the way Nepalese migrants in Myanmar use features of the natural environment in their homeland in metaphoric constructions of a cultural landscape expressing ethnic identity.
Gunnar Haaland
doaj +1 more source
Landscape History and Theory: from Subject Matter to Analytic Tool [PDF]
, 2004 This essay explores how landscape history can engage methodologically with the adjacent disciplines of art history and visual/cultural studies.
Birksted, Jan Kenneth
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The absence of absence: a (geographical hi)story of the landscape of Blackpool [PDF]
, 2008 Throughout the past decade contemporary human geography has seen a decisive move away from the structuralist analysis of the New Cultural era, to a more fluid, deconstructed and poststructuralist approach, perhaps best encapsulated within the ...
Shires, Kate
core
, 2023 Landscapes are important socio-ecological systems. They are widely researched through landscape ecology to aid conservation and environmental management efforts, yet these efforts are not always as successful as they could be in terms of on-the-ground ...
Julian Gorman, Diane Pearson
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