Results 61 to 70 of about 1,037,703 (310)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Forest drainage in the Hunsrück-Hochwald National Park - an integrative approach
Landscape OnlineThe management of drained wetlands has become a key focus in the implementation of climate change adaptation measures in recent years, particularly in forested areas.
Jörn Schultheiß, Werner Konold
doaj +1 more source
Mosaic of Israel’s landscapes as an expression of geographical, cultural, and religious diversity [PDF]
, 2019 Dorot Ruth, Mosaic of Israel’s landscapes as an expression of geographical, cultural, and religious diversity. “Images” vol. XXV, no. 34. Poznań 2019. Adam Mickiewicz University Press. Pp. 87–113. ISSN 1731-450X. DOI 10.14746/i.2019.34.06. Israel is tiny
Dorot , Ruth
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Preschoolers Learning with the Internet of Toys: From Toy-Based Edutainment to Transmedia Literacy
Seminar.net, 2018 The Internet of Toys (IoToys) as an emerging type of edutainment presents a new research area, especially in the context of learning. This study investigates four connected toys played with in the preschool context.
Katriina Heljakka, Pirita Ihamäki
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
EXPERIENCE OF LOCAL ZONING OF CULTURAL LANDSCAPES OF THE NORTH CAUCASUS
Наука. Инновации. Технологии, 2022 This paper deals with the theoretical and methodological problems of cultural landscape regionalization mikrogeograficheskom level research. As an example, the traditional IP-toric cultural landscape Stavropol Turkmen, urban cultural landscape of the ...
Alexey Vladimirovitsh Lysenko +2 more
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The landscapes of tourism space [PDF]
, 2009 The author attempts to define the term ‘tourism landscape’. It is treated as an important attribute of tourism space therefore, apart from its definition, the author presents its characteristic features and various types of such spaces with differing ...
Włodarczyk, Bogdan
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source