Results 31 to 40 of about 4,310,481 (293)

Understanding the cultural landscape value of traditional agrarian landscapes of African Sahara Desert: The case of Timimoun, Algeria

Journal of Design for Resilience in Architecture and Planning, 2022
In 1992, the World Heritage Convention became the first international legal instrument recognize cultural landscapes as a human heritage that must be protected.
Guerrout Chouaib, Bahar Baser Kalyoncuoglu   +1 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Does the place of residence affect land use preferences? Evidence from a choice experiment in Germany

Bio-based and Applied Economics, 2020
Discrete choice experiments can be used to inform policy makers on people’s preferences for landscapes and cultural ecosystem services. Recent studies have shown that the spatial context influences preferences and related willingness to pay values.
Julian Sagebiel, Klaus Glenk, Jürgen Meyerhoff   +2 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Disseminating the Past in 3D: O Corro dos Mouros and Its Ritual Landscape (Galicia, Spain)

Applied Sciences
This research presents a methodological approach combining UAV-LiDAR technology and SfM photogrammetry for the comprehensive documentation and analysis of O Corro dos Mouros, a Bronze-to-Iron Age archaeological site in the northwest of the Iberian ...
Mariluz Gil-Docampo, Rocío López-Juanes, Simón Peña-Villasenín, Pablo López-Fernández, Juan Ortiz-Sanz, María Pilar Prieto-Martinez   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Resurrecting India’s Struggle for Independence: Pioneering Role of Babu Jagat Singh

Space and Culture, India
Based on a five-year project (2019-2023) that investigated colonial correspondences and records held in various archives, a research document has been prepared to re-investigate the colonial history of the Banaras estate.
Rana P.B. Singh, Priyanka Jha
doaj   +1 more source

An interpretative model for the management of contemporary cultural landscapes in linear infrastructure projects

Journal of Environmental Engineering and Landscape Management, 2013
Structures and potentialities of cultural landscapes have been studied mostly under a historical perspective. This article questions if contemporary societies can develop cultural landscapes.
Elena Berte, Thomas Panagopoulos, Bruno Zanon   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Characterizing European cultural landscapes: Accounting for structure, management intensity and value of agricultural and forest landscapes

, 2023
We present a landscape characterization based on three dimensions of rural cultural landscapes. Landscapes are categorized using maps of landscape structure, management intensity, and landscape value and meaning.
Schulp, JE Catharina, Lieskovsky, Juraj, Kuemmerle, Tobias, Verburg, H Peter, Plieninger, Tobias, Tieskens, Frederik Koen, Levers, Christian   +6 more
core   +1 more source