Results 41 to 50 of about 3,877 (209)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The hidden cultural impact of climate-driven food security threats to landscapes

Cell Reports Sustainability
Climate change could severely affect traditional diets, ceremonies, and landscapes, eroding cultural identity and heritage. Some landscapes are unique because they reflect cultural identity linked to diet (e.g., rice terraces).
Paolo Tarolli, Edward Park, Dung Duc Tran, Ho Huu Loc, Wei Wei, Ciprian Mărgărint, Sumit Das, Antony Brown, Giulio Castelli   +8 more
doaj   +1 more source

Viticultural landscapes in transition: permanence and change

Miscellanea Geographica: Regional Studies on Development, 2018
This article concerns the transitions of cultural landscapes, especially of viticultural landscapes. The authors do not aim to present new definition of the term “landscape” but base their study on the existing output of Polish and foreign scholars.
Miętkiewska-Brynda Joanna, Makowski Jerzy   +1 more
doaj   +1 more source

Historical approach to evaluating productive cultural landscapes: A case study of Japanese vineyard landscapes

Japan Architectural Review, 2022
Cultural landscapes of vineyards and wineries are often evaluated based on their relationships to natural conditions or “terroir.” However, in vernacular evaluation, their meaning may need to be interpreted in the wider context of the region beyond the ...
Yoshito Kikuchi
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Semiotic of Cultural Landscapes in Cultural Geography; a Conceptual Approach for Detection and understanding Meaning [PDF]

Taḥqīqāt-i Farhangī-i Īrān, 2012
Studying the Location and spatial performances as a part of human behavioris discussed in semiotics nowadays. These man-made effectsare including information and meaning that is the subject of semiotics.
Ebrahim Fayaz, Hossein Sarfaraz, Ali Ahmadi   +2 more
doaj  

Far-Sightedness vs. Emergency: A Matter for “Not Outstanding” European Cultural Landscapes

Buildings, 2018
A far-sighted policy, designed to safeguard a State’s land and culture, is one that would be able to go beyond emergency culture in the direction of shared far-sightedness in the territorial government, looking ahead to future generations.
Rossella Salerno
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source