Results 61 to 70 of about 48,993 (305)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Far-Sightedness vs. Emergency: A Matter for “Not Outstanding” European Cultural Landscapes

Buildings, 2018
A far-sighted policy, designed to safeguard a State’s land and culture, is one that would be able to go beyond emergency culture in the direction of shared far-sightedness in the territorial government, looking ahead to future generations.
Rossella Salerno
doaj   +1 more source

Influence of the evolution of cultural landscapes as heritage on 20th century international heritage preservation doctrine

, 2021
Cari Goetcheus is a Professor of Historic Preservation in the College of Environment + Design at the University of Georgia. With training in both Landscape Architecture and Historic Preservation, Cari’s expertise lies in cultural landscape research ...
Mitchell, Nora J, Goetcheus, Cari
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Visual Quality Evaluation of Historic and Cultural City Landscapes: A Case Study of the Tai’erzhuang Ancient City

Buildings
As a World Cultural Heritage site, the Beijing–Hangzhou Grand Canal is lined with historic and cultural cities that bear abundant historical and cultural connotations.
Pengfei Du, Xinbei Man, Yanbo Wang, Yanfen Wang, Hanyue Li, Chenghan Yin, Zimin Lin, Junxi Fan   +7 more
doaj   +1 more source

Moorland landscapes in Switzerland. The changing significance of near-natural cultural landscapes [PDF]

, 2009
Switzerland has 89 “moorland landscapes of particular beauty and of national significance”. They consist of a large number of natural, near-natural and human-made elements, which entirely determine the character of each individual moorland landscape ...
Hammer, Thomas, Martellos, Stefano, Marion Leng, Leng, Marion, Stefano Martellos   +4 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Heritage Impact Assessment Index Within Urban Development Context: The Case of Masjed-e Jame of Isfahan in Iran

Heritage
Despite various opportunities, urban development projects have been causing significant challenges to the preservation and conservation of historic cultural heritage.
Baharak Ashrafi, Michael Kloos, Christa Reicher   +2 more
doaj   +1 more source

Cultural landscapes and ecotourism

, 2018
Cultural landscapes and ...
Marsia Marino
core  

Panel 2 Paper 2.2: Integrative Management Planning Framework for Sustainable Development of Sub-Saharan African World Heritage Cultural Landscapes

, 2019
Oris Malijani is a heritage professional working as a Principal Cultural Heritage Specialist in the Malawi Department of Culture. He work directly with local communities and other stakeholders in development and implementation of cultural heritage ...
Malijani, Oris
core   +1 more source