Results 61 to 70 of about 4,310,481 (293)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Panel 3 Constructing resilience: The entangled dimensions of nature and culture in agricultural landscapes and waterscapes

, 2019
Jessica Brown is Executive Director of the New England Biolabs Foundation, an independent, private foundation, and serves on the governing boards of Terralingua and International Funders for Indigenous Peoples.
Forde, Xavier, Brown, Jessica, Ishizawa, Maya, Ortsin, George, Lee, Kuang-Chung   +4 more
core   +1 more source

Viticultural landscapes in transition: permanence and change

Miscellanea Geographica: Regional Studies on Development, 2018
This article concerns the transitions of cultural landscapes, especially of viticultural landscapes. The authors do not aim to present new definition of the term “landscape” but base their study on the existing output of Polish and foreign scholars.
Miętkiewska-Brynda Joanna, Makowski Jerzy   +1 more
doaj   +1 more source

Social Valuation of Mediterranean Cultural Landscapes: Exploring Landscape Preferences and Ecosystem Services Perceptions through a Visual Approach

Land, 2020
Mediterranean cultural landscapes have been recognized as multifunctional landscapes that are currently threatened by two opposing trends: rural abandonment and agricultural intensification.
Íñigo Bidegain, César A. López-Santiago, José A. González, Rodrigo Martínez-Sastre, Federica Ravera, Claudia Cerda   +5 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Cultural landscapes and ecotourism

, 2018
Cultural landscapes and ...
Marsia Marino
core  

Visual Quality Evaluation of Historic and Cultural City Landscapes: A Case Study of the Tai’erzhuang Ancient City

Buildings
As a World Cultural Heritage site, the Beijing–Hangzhou Grand Canal is lined with historic and cultural cities that bear abundant historical and cultural connotations.
Pengfei Du, Xinbei Man, Yanbo Wang, Yanfen Wang, Hanyue Li, Chenghan Yin, Zimin Lin, Junxi Fan   +7 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Financing Sustainable Livestock Value Chains for Rangeland Restoration

, 2023
A Digital report by the Global Landscapes Forum on a round table session to discuss how linkages between sustainable livestock value chains and rangeland restoration can be strengthened.
Global Landscapes Forum
core   +1 more source