Results 71 to 80 of about 48,993 (305)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Untangling the Concept of Cultural Landscapes: A Critical Review
, 2020 In 1992, UNESCO’s World Heritage Convention was the first global legal instrument to recognise and protect cultural landscapes, setting a precedent for adoption of the concept within numerous national and international conservation designations and ...
Fogarty, Irene
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Globalisation - a threat to traditional landscapes and local identity? [PDF]
Traditional landscapes could be considered as one of the most apparent carriers of local identities. They act as memory of previous human activities. During the 1990s the economic changes have had a drastic influence on the appearance of these landscapes.
Hannes Palang +2 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Regeneration of urban cultural landscapes
Ochrona Dziedzictwa KulturowegoThe search for identity, the sense of belonging to a particular place, is a fundamental aspect of quality of life, whether the person is an inhabitant of a small village or an urban metropolis.
Monisha Jain, Prafulla Parlewar
doaj +1 more source
, 2006 Humans have always interacted with their environment and helped to create and modify the landscapes in which they live. The last decade or so has seen not only a significant increase in the scope, and in some instances, speed of such developments, but ...
S. Agostini +3 more
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Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Cultural landscapes represent the intersection of natural and cultural heritage, encompassing the physical environment as well as the cultural practices, traditions, and values associated with a specific place.
Wischott, Valerie +3 more
core +1 more source
Renewing Criminalized and Hegemonic Cultural Landscapes [PDF]
, 2014 The Mafia's long historical pedigree in Mezzogiorno, Southern Italy, has empowered the Mafioso as a notorious, uncontested, and hegemonic figure. The counter-cultural resistance against the mafiosi culture began to be institutionalized in the early 1990s.
Baris Cayli, Cayli, Baris
core +1 more source