Results 51 to 60 of about 48,993 (305)

Agricultural Landscapes: History, Status and Challenges

, 2021
Agricultural landscapes (rural landscapes, agrolandscapes) are territories shaped by agricultural production. They have enabled the development of human civilizations and are a cultural achievement.
Abdulla Saparov, Michael Manton, Angelstam, P., Eulenstein, F., Behrendt, A., Konstantin Pachikin, Dannowski, R., Jones, M., Nikolai M. Dronin, Per Angelstam, Viktor G. Sychev, Guy M. Robinson, Ilya Trofimov, Scheudzhen, A. K., Paul Poulton, Elmira Salnjikov, Ralf Dannowski, Blum, W. E. H., Salnjikov, E., Askhad K. Sheudzhen, Jörg Römbke, Poulton, P. R., Wilfried Mirschel, Rombke, J., Rainer Schreg, Schreg, R., Winfried E. H. Blum, Axel Behrendt, Schindler, U., Lothar Mueller, Dronin, N. M., Saparov, A., McKensie, B. M., Blair M. McKenzie, Olga V. Rukhovich, Mirschel, W., Uwe Schindler, Marc Antrop, Antrop, M., Hennings, V., Trofimov, I., Michael Jones, Vladimir A. Romanenkov, Volker Hennings, Manton, M., Robinson, G. M., Pachikin, K., Rukhovich, O. V., Romanenkov, V. A., Frank Eulenstein, Muller, L., Sychev, V. G.   +51 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Landscape and Meaning: Context for a global discourse on cultural landscape values

, 2020
One of our deepest needs is for a sense of identity and belonging. A common feature in this is human attachment to landscape and how we find identity in landscape and place.
Taylor, Ken
core  

Interfaces Among Placemaking and Cultural Landscapes: Review and Appraisal

, 2023
The concept of placemaking is used in comprehensive and complex ways in different contexts of disciplinary boundedness and application in prospective planning and pathways to sustainable development. There is no mutual agreement on a common definition
Olimpia Niglio, Rana P. B. Singh, Pravin S. Rana   +2 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The hidden cultural impact of climate-driven food security threats to landscapes

Cell Reports Sustainability
Climate change could severely affect traditional diets, ceremonies, and landscapes, eroding cultural identity and heritage. Some landscapes are unique because they reflect cultural identity linked to diet (e.g., rice terraces).
Paolo Tarolli, Edward Park, Dung Duc Tran, Ho Huu Loc, Wei Wei, Ciprian Mărgărint, Sumit Das, Antony Brown, Giulio Castelli   +8 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Viticultural landscapes in transition: permanence and change

Miscellanea Geographica: Regional Studies on Development, 2018
This article concerns the transitions of cultural landscapes, especially of viticultural landscapes. The authors do not aim to present new definition of the term “landscape” but base their study on the existing output of Polish and foreign scholars.
Miętkiewska-Brynda Joanna, Makowski Jerzy   +1 more
doaj   +1 more source

Social Valuation of Mediterranean Cultural Landscapes: Exploring Landscape Preferences and Ecosystem Services Perceptions through a Visual Approach

Land, 2020
Mediterranean cultural landscapes have been recognized as multifunctional landscapes that are currently threatened by two opposing trends: rural abandonment and agricultural intensification.
Íñigo Bidegain, César A. López-Santiago, José A. González, Rodrigo Martínez-Sastre, Federica Ravera, Claudia Cerda   +5 more
doaj   +1 more source