Results 231 to 240 of about 588,789 (303)

IAB 17th World Congress. [PDF]

Bioethics
Richie C.
europepmc   +1 more source

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, EarlyView.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

The Expanded Natural History of Song Discography, A Global Corpus of Vocal Music. [PDF]

Open Mind (Camb)
Bertolo M, Snarskis M, Kyritsis T, Yurdum L, Bainbridge CM, Atwood S, Hilton CB, Keomurjian A, Lee JS, Mackiel A, Mak V, Shin M, Bitran A, Shilton D, Delasanta L, Do HH, Lang J, Irani T, Kangatharan J, Lafleur K, Malko N, Atkinson QD, Singh M, Mehr SA.   +23 more
europepmc   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

The experience of a multidisciplinary team in welcoming vulnerable migrants in a rural Italian reception centre: a study using multidimensional textual analysis. [PDF]

BMC Nurs
Figura M, Pucciarelli G, Simeone S, Arcadi P, Uchmanowicz B, Vellone E, Alvaro R.   +6 more
europepmc   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Psychological Integrity and Ecological Repair: The Impact on Planetary Public Mental Health (A Narrative Review). [PDF]

Int J Environ Res Public Health
Jenkins M, Egger S.
europepmc   +1 more source

'Saying goodbye'. . . A systematic integrative review of palliative caregiving in intergenerational living contexts. [PDF]

Palliat Med
Juhrmann ML, Vandersman P, Damarell RA, Khamis Sharaf A, San Martin A, Donkor A, Salifu Y.   +6 more
europepmc   +1 more source

Exploring the social and organizational factors influencing dog bites: a qualitative study. [PDF]

BMC Public Health
Nohtani V, Mahdizadeh M, Gholian-Aval M, Ghavami V, Tehran H.   +4 more
europepmc   +1 more source