Results 1 to 10 of about 45,578 (261)

POTASSIUM ACCUMULATION IN THE PROXIMAL CONVOLUTED TUBULES OF THE FROG'S KIDNEY [PDF]

Journal of General Physiology, 1946
1. In a manner similar to that of the sartorius muscle, the isolated kidney of the frog can accumulate K against a gradient to upwards of three times its normal concentration. 2. The K-accumulating region is identified as the proximal tubule, which in the isolated tissue immersed over 24 hours in the cold (2–3°C.) amounts to about 90 per
Fitzgerald O, Conway E J
exaly   +4 more sources

Biology of the proximal tubule in body homeostasis and kidney disease

Nephrology Dialysis Transplantation
ABSTRACT The proximal tubule (PT) is known as the workhorse of the kidney, for both the range and magnitude of the functions that it performs. It is not only responsible for reabsorbing most solutes and proteins filtered by glomeruli, but also for secreting non-filtered substances including drugs and uremic toxins. The PT therefore plays
Craig Brooks, Andrew Hall, Ewout Hoorn   +2 more
exaly   +3 more sources

HEMOGLOBIN ABSORPTION BY THE CELLS OF THE PROXIMAL CONVOLUTED TUBULE IN MOUSE KIDNEY

Journal of Cell Biology, 1960
exaly  

Development of the proximal tubule of the fetal rat kidney : Morphometry and ultrastructural findings

Annals of Anatomy, 1993
Yoshio Morikawa, Toshiya Okada
exaly  

Kidney Injury Molecule-1 Is Specifically Expressed in Cystically-Transformed Proximal Tubules of the PKD/Mhm (cy/+) Rat Model of Polycystic Kidney Disease

International Journal of Molecular Sciences, 2016
Norbert Gretz, Anja Urbschat, Nicholas Obermüller   +2 more
exaly  

Retinoic acid receptor α activity in proximal tubules prevents kidney injury and fibrosis

Proceedings of the National Academy of Sciences of the United States of America
Xiaohan Tang, Changyuan Lu, Krysta Dikun   +2 more
exaly  

The Na+/H+ Exchanger 3 in the Intestines and the Proximal Tubule of the Kidney: Localization, Physiological Function, and Key Roles in Angiotensin II-Induced Hypertension

Frontiers in Physiology, 2022
The sodium (Na+)/hydrogen (H+) exchanger 3 (NHE3) is one of the most important Na+/H+ antiporters in the small intestines of the gastrointestinal tract and the proximal tubules of the kidney.
Sarah M. Nwia, Sarah M. Nwia, Xiao Chun Li, Xiao Chun Li, Ana Paula de Oliveira Leite, Ana Paula de Oliveira Leite, Rumana Hassan, Rumana Hassan, Jia Long Zhuo, Jia Long Zhuo   +9 more
doaj   +3 more sources

Clusterin marks maladaptive regenerative responses throughout the kidney following ischemia-reperfusion injury [PDF]

iScience
Summary: Our understanding of the regenerative capacity of renal tubules has primarily come from studies focusing on proximal tubules. To gain a broader view of injury responses throughout the tubular network, we employed single-cell RNA sequencing ...
Agnieszka Masztalerz, Loïck Joumier, Sunny Zhen, Tomoko Takano, Serge Lemay, Mohan Malleshaiah, Alex Gregorieff   +6 more
doaj   +2 more sources

Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes

Redox Biology
There is a large body of evidence implicating mitochondrial reactive oxygen species (ROS) overproduction and oxidative stress in the development of diabetic kidney disease and the deficiency of mitochondrial antioxidant systems in the kidney, such as ...
Inez A. Trambas, Lilliana Bowen, Vicki Thallas-Bonke, Matthew Snelson, Karly C. Sourris, Adrienne Laskowski, Michel Tauc, Isabelle Rubera, Guoping Zheng, David C.H. Harris, Phillip Kantharidis, Takahiko Shimizu, Mark E. Cooper, Sih Min Tan, Melinda T. Coughlan   +14 more
doaj   +3 more sources

TNF-α induces Claudin-1 expression in renal tubules in Alport mice

PLoS ONE, 2022
Claudin-1 (CL-1) is responsible for the paracellular barrier function of glomerular parietal epithelial cells (PEC) in kidneys, but the role of CL-1 in proximal tubules remains to be elucidated.
Manami Iida, Shuichi Ohtomo, Naoko A. Wada, Otoya Ueda, Yoshinori Tsuboi, Atsuo Kurata, Kou-ichi Jishage, Naoshi Horiba   +7 more
doaj   +2 more sources