Results 1 to 10 of about 140,068 (284)

Altered glycolipid metabolism during acute kidney injury exacerbates renal inflammation [PDF]

Scientific Reports
Acute kidney injury (AKI) can progress to chronic kidney disease (CKD), via a mechanism that is still largely unknown. We previously reported that glucosylceramide (GlcCer) acts as a damage-associated molecular pattern (DAMP) during AKI.
Akinori Osada, Miyako Tanaka, Yuki Sugiura, Xunmei Yuan, Shinji Yamashita, Kozue Ochi, Hiro Kohda, Ayaka Ito, Shiori Go, Tetsuya Okajima, Kenji Kadomatsu, Motoko Yanagita, Kazuhiro Furuhashi, Shoichi Maruyama, Takayoshi Suganami   +14 more
doaj   +2 more sources

TNF-α induces Claudin-1 expression in renal tubules in Alport mice

PLoS ONE, 2022
Claudin-1 (CL-1) is responsible for the paracellular barrier function of glomerular parietal epithelial cells (PEC) in kidneys, but the role of CL-1 in proximal tubules remains to be elucidated.
Manami Iida, Shuichi Ohtomo, Naoko A. Wada, Otoya Ueda, Yoshinori Tsuboi, Atsuo Kurata, Kou-ichi Jishage, Naoshi Horiba   +7 more
doaj   +2 more sources

mutation: a benign genetic cause of proteinuria? [PDF]

Childhood Kidney Diseases, 2023
Proteinuria is an important risk factor for renal and cardiovascular disease. It is associated with a risk for glomerulonephritis, chronic kidney disease, and end-stage renal disease.
Hyun Kyung Lee
doaj   +1 more source

micro-RNA-486-5p protects against kidney ischemic injury and modifies the apoptotic transcriptome in proximal tubules.

Kidney International, 2021
Acute kidney injury (AKI) carries high morbidity and mortality, and effective treatments are lacking. Preclinical models support involvement of micro-RNAs (miRs) in AKI pathogenesis, although effects on the kidney transcriptome are unclear. We previously
J. Viñas, Matthew Spence, C. J. Porter, A. Douvris, A. Gutsol, J. Zimpelmann, Pearl A Campbell, K. Burns   +7 more
semanticscholar   +1 more source

Morphological description and histological structure of the Hedgehog Kidney (Hemiechinus auritus)

Tikrit Journal of Pure Science, 2023
This study was aimed to recognize the morphological description and histological structure of the kidney in hedgehog (Hemiechinus auritus). The morphological results showed that the kidney has a small bean shape and reddish brown color.
Thekra Atta, Mohammed Nsaif Abbas, Luay Qasim, Ashwaq Talib, Mohammed Ali   +4 more
doaj   +1 more source

Expression of Bcl-2 and Bax in mouse renal tubules during kidney development. [PDF]

PLoS ONE, 2012
Bcl-2 and Bax play an important role in apoptosis regulation, as well as in cell adhesion and migration during kidney morphogenesis, which is structurally and functionally related to mitochondria.
Xiao-Feng Song, Hao Ren, Arne Andreasen, Jesper Skovhus Thomsen, Xiao-Yue Zhai   +4 more
doaj   +1 more source

3D proximal tubule-on-chip model derived from kidney organoids with improved drug uptake

Scientific Reports, 2022
Three-dimensional, organ-on-chip models that recapitulate kidney tissue are needed for drug screening and disease modeling. Here, we report a method for creating a perfusable 3D proximal tubule model composed of epithelial cells isolated from kidney ...
Jeffrey O. Aceves, Szilvia Heja, K. Kobayashi, Sanlin S. Robinson, Tomoya Miyoshi, Takuya Matsumoto, Olivier J. M. Schäffers, Ryuji Morizane, J. Lewis   +8 more
semanticscholar   +1 more source

Stx2 Induces Differential Gene Expression and Disturbs Circadian Rhythm Genes in the Proximal Tubule

Toxins, 2022
Shiga toxin-producing Escherichia coli (STEC) causes proximal tubular defects in the kidney. However, factors altered by Shiga toxin (Stx) within the proximal tubules are yet to be shown.
Fumiko Obata, Ryo Ozuru, Takahiro Tsuji, Takashi Matsuba, Jun Fujii   +4 more
doaj   +1 more source

Bioengineered Cystinotic Kidney Tubules Recapitulate a Nephropathic Phenotype

Cells, 2022
Nephropathic cystinosis is a rare and severe disease caused by disruptions in the CTNS gene. Cystinosis is characterized by lysosomal cystine accumulation, vesicle trafficking impairment, oxidative stress, and apoptosis. Additionally, cystinotic patients
Elena Sendino Garví, Rosalinde Masereeuw, Manoe J. Janssen   +2 more
doaj   +1 more source

New Insights into the Pathogenesis of Diabetic Nephropathy: Proximal Renal Tubules Are Primary Target of Oxidative Stress in Diabetic Kidney

Acta Histochemica et Cytochemica, 2020
Diabetic nephropathy is a major source of end-stage renal failure, affecting about one-third cases of diabetes mellitus. It has long been accepted that diabetic nephropathy is mainly characterized by glomerular defects, while clinical observations have ...
Ryuma Haraguchi, Y. Kohara, Kanako Matsubayashi, R. Kitazawa, S. Kitazawa   +4 more
semanticscholar   +1 more source