Results 11 to 20 of about 140,068 (284)

Decoding myofibroblast origins in human kidney fibrosis

Nature, 2020
Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present no antifibrotic therapies exist 1 – 3 . The origin, functional heterogeneity and regulation of scar-forming cells that occur during human kidney fibrosis remain ...
C. Kuppe, Mahmoud M. Ibrahim, J. Kranz, Xiaoting Zhang, S. Ziegler, J. Perales-Patón, J. Jansen, Katharina C. Reimer, James R. Smith, R. Dobie, John R Wilson-Kanamari, Maurice Halder, Yaoxian Xu, Nazanin Kabgani, Nadine Kaesler, Martin Klaus, Lukas Gernhold, Victor G. Puelles, T. Huber, P. Boor, Sylvia Menzel, R. Hoogenboezem, E. Bindels, J. Steffens, J. Floege, R. Schneider, J. Saez-Rodriguez, N. Henderson, R. Kramann   +28 more
semanticscholar   +3 more sources

Hnf4a is required for the development of Cdh6-expressing progenitors into proximal tubules in the mouse kidney

bioRxiv, 2020
Background Hnf4a is a major regulator of renal proximal tubule (PT) development. In humans, a mutation in HNF4A is associated with Fanconi renotubular syndrome (FRTS), which is caused by defective PT functions.
Sierra S. Marable, Eunah Chung, Joo-Seop Park   +2 more
semanticscholar   +1 more source

Fine Structure of the Trunk Kidney and Distribution of Its Secreted Exosomes in the Adult Zebrafish

Shiyan dongwu yu bijiao yixue, 2023
Objective To observe the fine structure of the trunk kidney in zebrafish, and to identify its secreted exosomes.Methods The microstructure and ultrastructure of the trunk kidney in zebrafish were observed by light microscopy and electron microscopy, and ...
LIN Jinxing, WANG Xindong, BAI Xuebing, FENG Liping, XIE Shuwu, CHEN Qiusheng   +5 more
doaj   +1 more source

The Na+/H+ Exchanger 3 in the Intestines and the Proximal Tubule of the Kidney: Localization, Physiological Function, and Key Roles in Angiotensin II-Induced Hypertension

Frontiers in Physiology, 2022
The sodium (Na+)/hydrogen (H+) exchanger 3 (NHE3) is one of the most important Na+/H+ antiporters in the small intestines of the gastrointestinal tract and the proximal tubules of the kidney.
Sarah M. Nwia, Sarah M. Nwia, Xiao Chun Li, Xiao Chun Li, Ana Paula de Oliveira Leite, Ana Paula de Oliveira Leite, Rumana Hassan, Rumana Hassan, Jia Long Zhuo, Jia Long Zhuo   +9 more
doaj   +1 more source

The kidney of the Nodularia freshwater mussel has a larger filtration-size and counter-current system with improved water excretion compared with the seawater mussel Mytilus

Biology Open, 2021
Histological studies and magnetic resonance imaging were employed to analyze the kidney structure and function of the freshwater mussel, Nodularia douglasiae. The Nodularia kidney consists of proximal, intermediate and distal tubules.
Eriko Seo, Hidefumi Wakashin, Yoshiteru Seo   +2 more
doaj   +1 more source

Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules.

JCI Insight, 2020
SGLT2 inhibitors are beneficial in halting diabetic kidney disease; complete mechanisms is unknown. The epithelial to mesenchymal transition (EMT) is associated with Sirt3 suppression and aberrant glycolysis.
Jinpeng Li, Haijie Liu, Susumu Takagi, Kyoko Nitta, Munehiro Kitada, S. Srivastava, Y. Takagaki, K. Kanasaki, D. Koya   +8 more
semanticscholar   +1 more source

Proximal Tubule p53 in Cold Storage/Transplantation-Associated Kidney Injury and Renal Graft Dysfunction

Frontiers in Medicine, 2021
Kidney injury associated with cold storage/transplantation is a primary factor for delayed graft function and poor outcome of renal transplants. p53 contributes to both ischemic and nephrotoxic kidney injury, but its involvement in kidney cold storage ...
Xiaohong Xiang, Xiaohong Xiang, Jiefu Zhu, Jiefu Zhu, Gang Zhang, Zhengwei Ma, Man J. Livingston, Zheng Dong, Zheng Dong   +8 more
doaj   +1 more source

Light chain proximal tubulopathy with lambda restriction presenting as acute kidney injury [PDF]

Journal of Nephropathology, 2021
Monoclonal gammopathies can produce a variety of glomerular, tubular, vascular and interstitial lesions. The spectrums of renal lesions produced by these monoclonal gammopathies include AL/AH amyloidosis, light chain cast nephropathy or myeloma kidney ...
Asha Thomas, Ram Prasad Elumalai, Barathi Gunabooshanam, Subalakshmi Balasubramanian, Jayakumar Matcha   +4 more
doaj   +1 more source

Inhalation of mercury vapor can cause the toxic effects on rat kidney [PDF]

, 2016
Dental amalgam has been used in dentistry as a filling material. The filler comprises mercury (Hg). It is considered one of the most important and widespread environmental pollutants, which poses a serious potential threat for the humans and animals ...
Akgul, Hayati Murat, Akgul, Nilgun, Altunkaynak, Berrin Zuhal, Altunkaynak, Muhammed Eyup, Deniz, Omur Gulsum, Unal, Deniz   +5 more
core   +1 more source

Notch activates Wnt-4 signalling to control medio-lateral patterning of the pronephros [PDF]

, 2009
Previous studies have highlighted a role for the Notch signalling pathway during pronephrogenesis in the amphibian Xenopus laevis, and in nephron development in the mammalian metanephros, yet a mechanism for this function remains elusive.
Jones, E. A., Naylor, Richard William
core   +1 more source