Results 31 to 40 of about 140,068 (284)

Sex-Specific Computational Models of Kidney Function in Patients With Diabetes

Frontiers in Physiology, 2022
The kidney plays an essential role in homeostasis, accomplished through the regulation of pH, electrolytes and fluids, by the building blocks of the kidney, the nephrons.
Sangita Swapnasrita, Aurélie Carlier, Anita T. Layton, Anita T. Layton   +3 more
doaj   +1 more source

Colocalization of GLUT2 glucose transporter, sodium/glucose cotransporter, and gamma-glutamyl transpeptidase in rat kidney with double-peroxidase immunocytochemistry. [PDF]

, 1992
Glucose is reabsorbed from the glomerular filtrate in the proximal segment of the renal tubule in two stages. The first stage is uphill transport across the brush border membrane by Na(+)-glucose cotransport and the second stage is downhill transport ...
Cramer, SC, Hirayama, BA, Pardridge, WM, Wright, EM   +3 more
core   +1 more source

Bioengineered kidney tubules efficiently excrete uremic toxins

Scientific Reports, 2016
The development of a biotechnological platform for the removal of waste products (e.g. uremic toxins), often bound to proteins in plasma, is a prerequisite to improve current treatment modalities for patients suffering from end stage renal disease (ESRD).
J. Jansen, Michele Fedecostante, M. Wilmer, J. G. Peters, U. Kreuser, P. V. D. van den Broek, R. A. Mensink, T. Boltje, D. Stamatialis, J. Wetzels, L. P. Van den Heuvel, J. Hoenderop, R. Masereeuw   +12 more
semanticscholar   +1 more source

Effects of Raw Ethanolic Seed Extract of Tetracarpidium conophorum on Heamatological and Histopathological Parameters in Swiss Albino Mice Infected with Plasmodium berghei [PDF]

, 2017
Study was carried out to determine the heamatological and histopathological effects of raw ethanolic seed extract of Tetracarpidium conophorum in swiss albino mice infected with Plasmodium berghei (NK65).
D. A. Oloruntola, E. O. Dada, I. B. Osho, O. O. Ogundolie   +3 more
core   +1 more source

Intratubular, Intracellular, and Mitochondrial Angiotensin II/AT1 (AT1a) Receptor/NHE3 Signaling Plays a Critical Role in Angiotensin II-Induced Hypertension and Kidney Injury

Frontiers in Physiology, 2021
Hypertension is well recognized to be the most important risk factor for cardiovascular diseases, stroke, and end-stage kidney failure. A quarter of the world’s adult populations and 46% of the US adults develop hypertension and currently require ...
Xiao Chun Li, Chih-Hong Wang, Ana Paula Oliveira Leite, Jia Long Zhuo   +3 more
doaj   +1 more source

Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

Scientific Reports, 2016
Three-dimensional models of kidney tissue that recapitulate human responses are needed for drug screening, disease modeling, and, ultimately, kidney organ engineering.
K. Homan, David B. Kolesky, Mark A. Skylar-Scott, J. Herrmann, Humphrey Obuobi, A. Moisan, J. Lewis   +6 more
semanticscholar   +1 more source

Fyn Phosphorylates Transglutaminase 2 (Tgm2) and Modulates Autophagy and p53 Expression in the Development of Diabetic Kidney Disease

Cells, 2023
Autophagy is involved in the development of diabetic kidney disease (DKD), the leading cause of end-stage renal disease. The Fyn tyrosine kinase (Fyn) suppresses autophagy in the muscle. However, its role in kidney autophagic processes is unclear.
Ryota Uehara, Eijiro Yamada, Shuichi Okada, Claire C. Bastie, Akito Maeshima, Hidekazu Ikeuchi, Kazuhiko Horiguchi, Masanobu Yamada   +7 more
doaj   +1 more source

Quantitative morphology of renal cortical structures during compensatory hypertrophy [PDF]

, 1998
The compensatory hypertrophy in different renal cortical structures was studied in rats 10 and 21 days after unilateral nephrectomy (UNX). Quantitative morphological/stereological analysis revealed significant increases in total renal cortical volume ...
Beck, Franz-X., Giebisch, Gerhard, Ohno, Akihiro, Pfaller, Walter, Seppi, Thomas   +4 more
core   +1 more source

Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes

Redox Biology
There is a large body of evidence implicating mitochondrial reactive oxygen species (ROS) overproduction and oxidative stress in the development of diabetic kidney disease and the deficiency of mitochondrial antioxidant systems in the kidney, such as ...
Inez A. Trambas, Lilliana Bowen, Vicki Thallas-Bonke, Matthew Snelson, Karly C. Sourris, Adrienne Laskowski, Michel Tauc, Isabelle Rubera, Guoping Zheng, David C.H. Harris, Phillip Kantharidis, Takahiko Shimizu, Mark E. Cooper, Sih Min Tan, Melinda T. Coughlan   +14 more
doaj   +1 more source

Current Perspective on the Location and Function of Gamma- Aminobutyric Acid (GABA) and its Metabolic Partners in the Kidney. [PDF]

, 2014
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter located in the mammalian central nervous system, which binds to GABAA and GABAB receptors to mediate its neurological effects.
Dunn, Kadeshia, Kelley, Stephen P., Peppiatt-Wildman, Claire M., Wildman, Scott S.P.   +3 more
core   +1 more source