Results 51 to 60 of about 140,068 (284)

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, EarlyView.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma, Yang Li, Shen Lin, Feifan Chu, Gaozhan Ren, Yinhui Mao, Mingzhi Wu, Yuning Ma, Qiwei Ji, Zujie Chen, Jinzhong Ji, Mingxin Sun, Yongpeng Xu, Xiaoli Sun, Longguang Tang, Hao Zhou   +15 more
wiley   +1 more source

Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury [PDF]

, 2019
TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia.
Choi, Soo Youn, Kang, Hyun Je, Kwon, Hyug Moo, Kwon, Mi Jin, Lee-Kwon, Whaseon, Lim, Sun Woo, Nam, Dougu, Park, Hyun, Sanada, Satoru, Yoo, Eun Jin, Yoon, Sora   +10 more
core   +1 more source

NSUN5 Attenuates Renal Injury and Ferroptosis in Hyperuricaemic Nephropathy Through YBX2‐Dependent Stabilisation of SCD1 m5C Methylation

Advanced Science, EarlyView.
NSUN5 is downregulated in hyperuricaemic nephropathy. Overexpression of NSUN5 enhances the stability of SCD1 mRNA through the m5C reader YBX2, ultimately inhibiting ferroptosis in renal tubular epithelial cells. Additionally, this axis suppresses the NF‐κB signaling pathway to alleviate inflammation and upregulates ABCG2 to promote uric acid excretion,
Xiu‐xiu Song, Xiao‐guo Suo, Yue Yu, Kuo Zhang, Chen‐ao Li, Jie Wang, Hui‐xia Xu, Si‐yu Niu, Dong‐xue Lv, Zi‐hao He, Feng‐he Li, Xiao‐ming Meng, Juan Jin   +12 more
wiley   +1 more source

Spatio-temporal expression of membrane transporters, Megalin and Cubilin, in renal development of C57BL/6 mice

陆军军医大学学报
Objective To observe the distribution of membrane transporters, Megalin and Cubilin, in the renal development of mice, and to reveal the temporal and spatial rules of their functional differentiation during renal development.
LUO Mei, ZHAI Xiaoyue, MA Yunsheng
doaj   +1 more source

Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin. [PDF]

PLoS ONE, 2014
Obesity is a common and complex health problem, which impacts crucial organs; it is also considered an independent risk factor for chronic kidney disease.
Alessandra Stacchiotti, Gaia Favero, Lorena Giugno, Antonio Lavazza, Russel J Reiter, Luigi Fabrizio Rodella, Rita Rezzani   +6 more
doaj   +1 more source

Histopathological analysis and in situ localisation of Australian tiger snake venom in two clinically envenomed domestic animals [PDF]

, 2011
Objective: To assess histopathological changes in clinically envenomed tiger snake patients and identify tissue specific localisation of venom toxins using immunohistochemistry.
Balmer, L., Brown, S.G.A., Davern, K.M., Jacoby-Alner, T.E., Stephens, N., Swindells, K.   +5 more
core   +2 more sources

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Morfometría de cortes histológicos de los túbulos renales normales en una muestra de humanos adultos

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2017
Fundamento: los túbulos renales normales se han descrito por morfometría, lo que permite “reconstruir” en tercera dimensión la forma y el tamaño del espécimen estudiado.Objetivo: caracterizar la magnitud de los túbulos renales normales en humanos adultos,
Miosotis de Lourdes Fernández Lastre, Iraldo Mederos Pérez, Yardelys Rego Juhe, Sandor Varela Iraola, Tamara Caraballoso Recio   +4 more
doaj  

Enhancement of HGF-induced tubulogenesis by endothelial cell-derived GDNF [PDF]

, 2019
学位記番号 ...
Nakasatomi, Masao, ナカサトミ, マサオ, 中里見, 征央   +2 more
core