Results 71 to 80 of about 45,578 (261)

An all‐in‐one fucosylated gold nanocluster probe enables NIR‐II imaging and multi‐mechanistic therapy of acute kidney injury

BMEMat, EarlyView.
This study developed a fucoside‐targeted gold nanocluster probe that enables early NIR‐II imaging and multi‐mechanistic therapy for acute kidney injury, effectively mitigating oxidative stress, modulating inflammatory responses, and inhibiting ferroptosis to improve renal outcomes. Abstract Acute kidney injury (AKI) remains a life‐threatening condition
Ping Zhang, Boning Tan, Suqing Feng, Beibei Gu, Ting Feng, Haiguang Zhu, Jianping Xie, Xun Yuan   +7 more
wiley   +1 more source

PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubulesResearch in context

EBioMedicine, 2018
Background: The renal tubules, which have distant metabolic features and functions in different segments, reabsorb >99% of approximately 180 l of water and 25,000 mmol of Na + daily.
Zhongshi Lyu, Zhaomin Mao, Qianyin Li, Yan Xia, Yamin Liu, Qingling He, Yingchun Wang, Hui Zhao, Zhimin Lu, Qin Zhou   +9 more
doaj   +1 more source

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová, Fabian Müller, Daniel Auge, Jörg König, Martin F. Fromm, Arne Gessner   +5 more
wiley   +1 more source

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects

Developmental Dynamics, EarlyView.
Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick, Lorraine Eley, Deborah J. Henderson, Bill Chaudhry   +3 more
wiley   +1 more source

BMP-7 Protein Expression Is Downregulated in Human Diabetic Nephropathy

Acta Clinica Croatica, 2015
Bone morphogenetic protein-7 (BMP-7) is expressed in all parts of the normal kidney parenchyma, being highest in the epithelium of proximal tubules. It protects kidney against acute and chronic injury, inflammation and fibrosis.
Renata Ivanac-Janković, Marijana Ćorić, Vesna Furić-Čunko, Vesna Lovčić, Nikolina Bašić-Jukić, Petar Kes   +5 more
doaj  

Expression of metallothionein in renal tubules of rats exposed to acute and endurance exercise.

Folia Histochemica et Cytobiologica, 2006
The induction of exercise-induced apoptosis in not actively involved in exercise organs, such as kidney could be a result of oxidative stress. Metallothionein (MT) exerts a protective effect in the cell against oxidative stress and apoptosis.
Katia Rossini, Zbigniew Jethon, Marek Cegielski, Małgorzata Dumańska, Barbara Dolińska-Krajewska, Piotr Dziegiel, Marzena Podhorska-Okołów, Ugo Carraro, Maciej Zabel   +8 more
doaj   +1 more source

Endocytic adaptation to functional demand by the kidney proximal tubule

The Journal of Physiology, 2021
AbstractThe kidney proximal tubule (PT) efficiently recovers the low level of albumin and other proteins that normally escape the glomerular filtration barrier. Two large receptors, megalin and cubilin/amnionless (CUBAM), bind to and efficiently retrieve these predominantly low molecular‐weight proteins via clathrin‐mediated endocytosis.
openaire   +3 more sources

Meta‐analysis of sotagliflozin, a dual sodium‐glucose‐cotransporter 1/2 inhibitor, for heart failure in type 2 diabetes

ESC Heart Failure, Volume 12, Issue 2, Page 968-979, April 2025.
Abstract Sodium‐glucose co‐transporters (SGLTs) mediate sodium and glucose transport across cell membranes. SGLT2 inhibitors have a recognized place within heart failure (HF) guidelines. We evaluated the effect of sotagliflozin on HF and cardiovascular outcomes in participants with type 2 diabetes. Scopus, Medline, Embase and Central were searched from
Maria Anna Bantounou, Panagiotis Sardellis, Josip Plascevic, Ribeya Awaes‐Mahmood, Justyna Kaczmarek, Daniel Black Boada, Rosa Thuemmler, Sam Philip   +7 more
wiley   +1 more source

EPRS1-mediated fibroblast activation and mitochondrial dysfunction promote kidney fibrosis

Experimental and Molecular Medicine
Kidney fibrosis causes irreversible structural damage in chronic kidney disease and is characterized by aberrant extracellular matrix (ECM) accumulation.
Seung Seob Son, Hee Seul Jeong, Seong-Woo Lee, Eun Soo Lee, Jeong Geon Lee, Ji-Hye Lee, Jawoon Yi, Mi Ju Park, Min Sun Choi, Donghyeong Lee, Sin Young Choi, Jiheon Ha, Jeong Suk Kang, Nam-Jun Cho, Samel Park, Hyo-Wook Gil, Choon Hee Chung, Joon Seok Park, Myung Hee Kim, Jihwan Park, Eun Young Lee   +20 more
doaj   +1 more source

Impact of gender in early structural changes of contrast induced nephropathy in rats

Brazilian Journal of Nephrology
Introduction: Contrast-induced nephropathy (CIN) is a major iatrogenic cause of acute kidney injury. Experimental studies have shown that intravascular injection causes intense vacuolization of the contrast agent in the proximal renal tubules cells ...
José Carlos Carraro-Eduardo, Mariana Franco Ferraz Santino, Heloisa Werneck de Macedo, Licínio Esmeraldo da Silva   +3 more
doaj   +1 more source