Results 31 to 40 of about 10,059 (261)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

L’eau urbaine ou le pouvoir de renaturer

Cybergeo, 2004
Many urban policies (urban renewal, waterfront renewal, environmental protection, leisure and cultural amenities development, public spaces development…) focus on the water in the city (river, Lake, sea…). These urban policies are in competition in order
Franck Scherrer
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Evaluation of Underground Space Resources in Ancient Cities from the Perspective of Organic Renewal: A Case Study of Shaoxing Ancient City

ISPRS International Journal of Geo-Information
China has entered a period of urban renewal, with the focus shifting from large-scale incremental construction to both upgrading existing building quality and adjusting incremental structures.
Qiuxiao Chen, Yiduo Qi, Guanjie Xu, Xiuxiu Chen, Xiaoyi Zhang, Hongbo Li   +5 more
doaj   +1 more source

Beyond multiculturalism. Teaching history and the renewal of a cultural perspective

Didattica della storia, 2020
One of the main task of the education in school should be to contribute to the development of a sense of belonging, to foster social integration and to promote the hope of human growth for the youth it cares for, since every person needs to constantly ...
Antonia Grasselli
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

A Comparative Study of Traditional Village Renewal Characteristics Driven by Different Entities from the Perspective of Place-Making

Buildings
The renewal of traditional villages should not only focus on the protection of cultural heritage but also comprehensively consider the development of social, economic, and environmental aspects. The concept of place-making offers an effective strategy to
Naifei Liu, Huinan Zhang
doaj   +1 more source

Liturgiese sang op die kruispad tussen tradisie en vernuwing

Acta Theologica, 1997
The renewal of liturgical singing has become an important issue in the Afrikaans-speaking reformed churches. In the process of renewal the theological essence and the ecumenical character of Christian liturgy should be kept in mind, as well as the ...
WML Strydom
doaj   +1 more source