Results 41 to 50 of about 365,705 (305)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

L’eau urbaine ou le pouvoir de renaturer

open access: yesCybergeo, 2004
Many urban policies (urban renewal, waterfront renewal, environmental protection, leisure and cultural amenities development, public spaces development…) focus on the water in the city (river, Lake, sea…). These urban policies are in competition in order
Franck Scherrer
doaj   +1 more source

Beyond multiculturalism. Teaching history and the renewal of a cultural perspective

open access: yesDidattica della storia, 2020
One of the main task of the education in school should be to contribute to the development of a sense of belonging, to foster social integration and to promote the hope of human growth for the youth it cares for, since every person needs to constantly ...
Antonia Grasselli
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

open access: yesFEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

Evaluation of Underground Space Resources in Ancient Cities from the Perspective of Organic Renewal: A Case Study of Shaoxing Ancient City

open access: yesISPRS International Journal of Geo-Information
China has entered a period of urban renewal, with the focus shifting from large-scale incremental construction to both upgrading existing building quality and adjusting incremental structures.
Qiuxiao Chen   +5 more
doaj   +1 more source

Conservation of the Land Walls Protection Area by Renewal (!): Evaluating the Spatial Effects of the Law No. 5366 Through 'Zeytinburnu Culture Valley Project' of Istanbul

open access: yesMegaron, 2018
The urban transformation process accelerated immensely by the end of the 20th century is one of the problems Turkey has faced. This process, which is guided by various legal and administrative sanctions for many years, affects historical urban areas ...
Elifnaz Durusoy, Mehmet Cengiz Can
doaj   +1 more source

Cities of culture and the regeneration game [PDF]

open access: yes, 2011
Capital of Culture (ECoC) programme exactly a year on from its inauguration. This event also saw the transition from Liverpool's "Year of Culture 08‟ to "Year of Environment 09" and a simultaneous event in the Austrian city of Linz to which the Capital ...
Evans, GL
core  

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji   +13 more
wiley   +1 more source

A Comparative Study of Traditional Village Renewal Characteristics Driven by Different Entities from the Perspective of Place-Making

open access: yesBuildings
The renewal of traditional villages should not only focus on the protection of cultural heritage but also comprehensively consider the development of social, economic, and environmental aspects. The concept of place-making offers an effective strategy to
Naifei Liu, Huinan Zhang
doaj   +1 more source

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