Results 41 to 50 of about 10,059 (261)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Conservation of the Land Walls Protection Area by Renewal (!): Evaluating the Spatial Effects of the Law No. 5366 Through 'Zeytinburnu Culture Valley Project' of Istanbul

Megaron, 2018
The urban transformation process accelerated immensely by the end of the 20th century is one of the problems Turkey has faced. This process, which is guided by various legal and administrative sanctions for many years, affects historical urban areas ...
Elifnaz Durusoy, Mehmet Cengiz Can
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Exploring Livable Communities in Urban Renewal: Case Study of China’s Metropolises

Buildings
As urban boundaries continue to expand and core city areas undergo optimization, megacities such as New York, London, Beijing, Shanghai, and Guangzhou exert a siphon effect on surrounding regions, intensifying population concentration and land demand ...
Ben Xiang, Mingjie Liang, Jianjun Ma, Chenzhe Ouyang, Jiaxin Lu   +4 more
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Economic Feasibility Assessment of Industrial Heritage Reuse Under Multi-Attribute Decision-Based Urban Renewal Design

Urban Science
Industrial heritage is increasingly becoming an important resource for sustainable urban renewal. With the acceleration of deindustrialization and urban transformation, Adaptive Reuse (AR) is regarded as the core path connecting heritage protection and ...
Shuxuan Meng, Jingbo Zhang, Lei Xiong
doaj   +1 more source

Renewing Strength: Corporate Culture Revisited

M@n@gement, 2003
The management of corporate culture is explored through a series of reflections upon literature that has fashioned and addressed this field. Specifically, the article considers the motivation, key elements and continuing relevance of the critique made in “Strength is Ignorance; Slavery is Freedom” (Willmott, 1993) where, by pointing to their incipient ...
openaire   +2 more sources

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Sustainable Heritage Renewal in China: A Multi-Criteria Decision Framework Integrating Cultural Authenticity and Technological Intervention

Buildings
This study investigates the interrelationship between artistic, architectural, and technological interventions and cultural continuity in the heritage renewal process in China from a sustainability-oriented design perspective.
Huidong Li, Veerawat Sirivesmas, Weixiao Zhang   +2 more
doaj   +1 more source