Results 41 to 50 of about 3,146,979 (345)

Supporting arts and enterprise skills in communities through creative engagement with the local area [PDF]

open access: yes, 2011
The project proposes a framework and methodology of artistic and creative social intervention that empowers and supports engagement with communities of young people affected by change in their local environment.
Haywood, P, Ingleson, SJ
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Cultural accessible pedestrian ways. The case of Faro historic centre [PDF]

open access: yes, 2020
In a historic city the existence of accessible pedestrian routes constitutes an essential feature to a true access to culture heritage, contributing for processes of social inclusion.
Landim, Isabel Tavares   +2 more
core  

MçTAZELE AND THEIR INTELLECTUAL AND THEIR CULTURAL RENEWAL [PDF]

open access: yesتاریخ اسلام, 2004
Abbasids Caliphs paid a considerable attention to the Mئtazele's trend of thinking during thirty years (in the era of Mؤmoon, Mئtasem and Vathegh). In 232 A.H.
Hosein Moftakhari, Ali Fath Ghobadpour
doaj  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Renewal of Buenos Aires city waterfront [PDF]

open access: yes, 2010
This paper reports an analysis of the main phases and factors relevant to the renovation of the coastal area of the city of Buenos Aires. Since the early 1980s, and especially with the country's comeback of democratic life, that area developed along two ...
Faggi, Ana Maria
core   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

Branding the Games: Commercialism and the Olympic City [PDF]

open access: yes, 2009
This chapter examines the role of branding and sponsorship in the Olympic games - with particular reference to the urban. The chapter identifies tensions between Olympic values, branding activities and a projected legacy.
MacRury, Iain
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

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