Results 51 to 60 of about 6,322,087 (302)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The safety culture stack – the next evolution of safety culture? [PDF]
Safety and Reliability, 2018 Since its inception following the Chernobyl nuclear power plant disaster in 1986, safety culture has impacted a number of industries, including nuclear power, the oil and gas industry, rail, health...
Barry Kirwan, Tom Reader, Anam Parand
openaire +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
ChildrenBackground: Children’s development is dependent on a range of factors influencing their life course outcomes. Protective and challenging social and cultural determinants impact how Indigenous families support their children’s developmental foundations ...
Akilew Awoke Adane +6 more
doaj +1 more source
Colonial Legacies and Collaborative Action: Improving Indigenous Peoples’ Health Care in Canada
International Indigenous Policy Journal, 2020 Indigenous people experience significant health disparities compared to non-Indigenous people, which are exacerbated by less accessible and poorer quality health care services.
Lloy Wylie +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Critical Public HealthIntroduction Culturally responsive family and kinship-focused care is crucial for equity and inclusion of Aboriginal and Torres Strait Islander People in public health and healthcare settings.
Melissa Arnold-Ujvari +3 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Response to Cooney Article, “a Comparative Analysis of Transcultural Nursing & Cultural Safety” [PDF]
, 1996 The purpose of Cooney's article is stated as "...to consider the similarities and differences between transcultural nursing and cultural safety..." (p.6).
Madeleine Leininger
core
When ‘disorder’ doesn’t translate: DSM categories, lived illness and social sickness across cultures
BJPsych BulletinDiagnostic classifications (DSM, ICD and other system frameworks) make distress legible for clinical and institutional action. That is their strength.
Yasuhiro Kotera
doaj +1 more source