Results 101 to 110 of about 5,587,139 (296)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Cartografía Colombia en un tambor
Esta cartografía presenta un recorrido por la riqueza y diversidad de tambores y expresiones musicales que narran nuestra historia y nuestra fuerza vital.
Bogotá : Corporación Cultural Cabildo
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Culturally Sensitive Learning Practices
IASL Annual Conference Proceedings, 2011 In today’s global world, to provide meaningful education, teacher-librarians and their students need to become culturally competent: open to learning about other cultures and sharing one’s own culture, able to change personal perspectives, and able to communicate effectively across cultures.
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Cultural Impact Indexes: background, methodology and results
, 2017 The result recorded in this document is summarized as a methodological finding that can be used to define a battery of cultural effect and impact indicators and to construct cultural impact indexes.
Banco de la República (Bogotá). Subgerencia Cultural; Barona Tovar, Fernando; Cuéllar Caicedo, Edwin Javier
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Culturally Sensitive Perinatal Mental Health Care: Experiences of Women From Minority Ethnic Groups
Health ExpectationsBackground Current research has identified how ethnic minority women experience poorer health outcomes during the perinatal period. In the United Kingdom, specialist perinatal mental health services provide mental health treatment for women throughout ...
Angelene Gardner +2 more
doaj +1 more source