Results 41 to 50 of about 1,232,477 (291)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Researching in-between experience and reality [PDF]

, 2012
In this article, we draw on LORENZER's method in our analysis of a single case data extract derived from a research project generating data through the Tavistock Infant Observation tradition.
Froggett, Lynn, Holloway, Wendy
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

WHEN CULTURE MEETS RELIGION: THE MULUDAN TRADITION IN THE KA-NOMAN SULTANATE, CIREBON, WEST JAVA

Al-Albab, 2013
This article is based on a fundamental question, what is the relationship between practicing the Muludan tradition and seeking of power by the Royal family of the Kanoman Sultanate in Cirebon? The Muludan is a tradition conducted by the Royal family, and
Mohamad Yusuf
doaj   +1 more source

Oral Traditions Under Threat: The Australian Aboriginal Experience [PDF]

, 1991
Many writers in Australia have written about the economic and social effects of the written tradition upon the various oral traditions of Australia, but few have addressed the inappropriateness of replacing the oral tradition with a written one.
Morris, Christine
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Tradisi lisan, naskah, dan sejarah Sebuah catatan politik kebudayaan

Wacana: Journal of the Humanities of Indonesia, 2005
Tradition can be seen from two different perspectives, those of literacy (writing system) and of oral tradition. Recently, some intellectuals have shown interest in oral tradition as academic study in some universities.
I Nengah Duija
doaj   +1 more source

Cumulative culture and complex cultural traditions [PDF]

Mind & Language, 2020
Cumulative cultural evolution is often claimed to be distinctive of human culture. Such claims are typically supported with examples of complex and historically late‐appearing technologies. Yet by taking these as paradigm cases, researchers unhelpfully lump together different ways that culture accumulates.
openaire   +2 more sources

Introduction: Legal Form and Cultural Symbol – Music, Copyright and Information Studies [PDF]

, 2009
Writers in information and communication studies often assume the stability of objects under investigation: network nodes, databases, information.
Kretschmer, Martin, Pratt, A.
core