Results 31 to 40 of about 45,388 (268)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
ÎNTRE IDENTITATEA NAŢIONALĂ ŞI IDENTITATEA EUROPEANĂ
EIRP Proceedings, 2008 The context of european integration resulted in numerous questions and controversesregarding maintaining the national identity of each nation, once i twill obtain the membership of the EuropeanUnion.Many states saw this process as giving up the ...
Gina Livioara Goga
doaj
Česká katolická recepce pravoslavných filozofů a teologů ve 20. až 40. letech 20. století
Studia Historica Brunensia, 2017 This article examines the Catholic reception of works published in journals in the first half of the 20th century by Orthodox philosophers, theologians and writers, and explains their importance in Czech culture during this period.
Jiří Hanuš, Petr Husák
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Cumulative culture and complex cultural traditions [PDF]
Mind & Language, 2020 Cumulative cultural evolution is often claimed to be distinctive of human culture. Such claims are typically supported with examples of complex and historically late‐appearing technologies. Yet by taking these as paradigm cases, researchers unhelpfully lump together different ways that culture accumulates.
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Japanese gardens outside of Japan: from the export of art to the art of export
Journal of Architecture and Urbanism, 2011 Since the 19th century, a Japanese garden as a cultural phenomenon with a millennium-old history of religion and philosophy-based landscaping art has been exported to different regions of the globe and built in countries far from the land of its origin ...
Gintaras Stauskis
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Appartenances & Altérités, 2023 This article describes the emergence in the 2000s of debates about the globalized appropriation of traditional Brazilian percussion music by mostly amateur members of foreign groups called batucadas (particularly in France or samba schools, blocos ...
Anaïs Vaillant
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source