Results 41 to 50 of about 45,388 (268)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Teachers’ perceptions on the effectiveness of private tutoring in Malaysia

Revue Internationale d’Éducation de Sèvres, 2014
This paper examines teachers’ perceptions of the effectiveness of private tutoring in Malaysia. Drawing on survey data from Perak, Selangor, and Wilayah Persekutuan, the findings suggest that teachers perceive tutoring to be effective both in increasing ...
Husaina Banu Kenayathulla
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

ДО ІСТОРІЇ МІСЬКОГО СВЯТА (УКРАЇНСЬКО-НІМЕЦЬКІ ПАРАЛЕЛІ) / To the History of Urban Holidays (Ukrainian-German Parallels)

Актуальні питання суспільних наук та історії медицини, 2015
Курочкин Олександр. К истории городского праздника (украинско-немецкие параллели). Долгое время украинская народоведческая наука занималась преимущественно изучением культуры и быта сельского населения.
Курочкін Олександр
doaj  

Reflections on Traditional Chinese Medicine's Modernization

Yixue yu zhexue
The concept of cultural tradition emphasizes the intrinsic cultural genes of tradition, while traditional culture focuses more on the socio-cultural conditions of the present, highlighting the temporal and contextual presence of culture.
Weihua PENG
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The Reinvention of Tradition in Making and Exhibiting of Dowry in Anatolian Culture [PDF]

Pad, 2021
Marriage is a significant part of almost every culture. As a cultural phenomenon, marriage consists of traditional patterns that connect material and spiritual culture and give it belonging to a culture.
Aybeniz Gökmen, Fatma Nur Gökdeniz Zeynali   +1 more
doaj  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

NYÈSÈK 'S CULTURAL TRANSFORMATION IN THE SASAK TRIBE COMMUNITY IN SADE TOURISM VILLAGE, CENTRAL LOMBOK

E-Journal of Cultural Studies
Sade is a hamlet inhabited by the Sade indigenous peoples in Central Lombok. The culture of the ancient Sasak tribe is still implemented by the Sade people to this day. One of them is the Nyèsèk tradition.
Evit Nurul Setianny
doaj   +1 more source