Results 41 to 50 of about 3,403,718 (262)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Re-framing the Spanish Civil War as ‘Cultural Trauma’: When Responsibilities Get Blurred After Violence [PDF]
University of Bucharest Review. Literary and Cultural Studies Series, 2019 The aim of this article is to address to what extent some institutional form of remembering the Spanish Civil War (1936-1939) as a collective trauma could be considered an instance of Jeffrey Alexander and Neil Smelzer´s notion of ’cultural trauma ...
Rafael Pérez Baquero
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Displaced Borders: The Written Traumatic Borderline between Pskov Province and Chechnya
Culture Unbound: Journal of Current Cultural Research, 2014 This article examines the narrative construction of borders through an analysis of "non-professional writing" produced by the residents of Pskov. It discusses the construction of national borders and the symbolic meanings invested in them, with the ...
Mari Ristolainen
doaj +2 more sources
Cultural Trauma in Patricia Grace’s Potiki
Polilog: Studia NeofilologiczneAfter around a hundred years of British colonial domination New Zealand became an independent country in 1947. Yet, it took another thirty years for its native writers to regain the New Zealand voice and ‘write back,’ to (re)tell the story of the people
Ewa Kroplewska-Kuśnierz
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
How pain becomes common? Cultural trauma as a process
Studia Humanitatis, 2018 The article reviews the process and peculiarities of the transition of personal trauma into cultural one. The diaries of inhabitants of the besieged Leningrad became the source for the research.
Golovashina Oksana Vladimirovna
doaj
Triumph and Trauma: Justifications of Mass Violence in Deuteronomistic Historiography
Open Theology, 2022 This article investigates the justifications of mass violence in Deuteronomistic historiography through the lens of cultural trauma. The analysis concentrates on the representation and justification of mass violence, that is mass killings and other forms
Markl Dominik
doaj +1 more source
Collective memories and cultural trauma of different generational groups
Social psychology and society, 2019 The article theoretically substantiated the approach to the study of cultural trauma through the analysis of memories of generations, characterized by signs of injury.
V. A. Baranova, A. Dontsov
semanticscholar +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source