Results 1 to 10 of about 375,429 (120)

Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism

BMC Neuroscience, 2021
Background Autism spectrum disorder (ASD) is characterized by the core symptoms of impaired social interactions. Increasing evidence suggests that ASD has a strong genetic link with mutations in chromodomain helicase DNA binding protein 8 (CHD8), a gene ...
Stanislav M. Cherepanov, Maria Gerasimenko, Teruko Yuhi, Kazumi Furuhara, Chiharu Tsuji, Shigeru Yokoyama, Keiichi I. Nakayama, Masaaki Nishiyama, Haruhiro Higashida   +8 more
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Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

Frontiers in Neuroscience, 2022
Investigating the neurocircuit and synaptic sites of action of oxytocin (OT) in the brain is critical to the role of OT in social memory and behavior.
Haruhiro Higashida, Haruhiro Higashida, Kazumi Furuhara, Olga Lopatina, Olga Lopatina, Maria Gerasimenko, Osamu Hori, Tsuyoshi Hattori, Yasuhiko Hayashi, Stanislav M. Cherepanov, Anna A. Shabalova, Alla B. Salmina, Alla B. Salmina, Kana Minami, Teruko Yuhi, Chiharu Tsuji, PinYue Fu, Zhongyu Liu, Shuxin Luo, Anpei Zhang, Shigeru Yokoyama, Satoshi Shuto, Mizuki Watanabe, Koichi Fujiwara, Sei-ichi Munesue, Ai Harashima, Yasuhiko Yamamoto   +26 more
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Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder

Scientific Reports, 2020
Oxytocin (OT) is a critical molecule for social recognition and memory that mediates social and emotional behaviours. In addition, OT acts as an anxiolytic factor and is released during stress. Based on the activity of CD38 as an enzyme that produces the
Maria Gerasimenko, Stanislav M. Cherepanov, Kazumi Furuhara, Olga Lopatina, Alla B. Salmina, Anna A. Shabalova, Chiharu Tsuji, Shigeru Yokoyama, Katsuhiko Ishihara, Charles Brenner, Haruhiro Higashida   +10 more
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A mindfulness-based intervention adapted to dementia caregivers: A study protocol for a randomized clinical control trial

Frontiers in Psychology, 2022
Dementia caregiving, besides encompassing various challenges in tandem to the diagnosis of the care recipient, is associated with decreased psychological well-being and mental health.
Rea Antoniou, Despoina Georgakopoulou Toli, Hannah Lerner, Patrick Callahan, Roger Coble, Bailey Ortiz, Alissa Bernstein Sideman, Alissa Bernstein Sideman, Alissa Bernstein Sideman, Alissa Bernstein Sideman, Suzanne M. Shdo, Suzanne M. Shdo, Robert W. Levenson, Nuno Ferreira, Judith T Moskowitz, Katherine P. Rankin   +15 more
doaj   +1 more source

Receptor for advanced glycation end-products and child neglect in mice: A possible link to postpartum depression

Comprehensive Psychoneuroendocrinology, 2022
The receptor for advanced glycation end-products (RAGE), a pattern recognition molecule, has a role in the remodeling of vascular endothelial cells mainly in lungs, kidney and brain under pathological conditions.
Haruhiro Higashida, Maria Gerasimenko, Yasuhiko Yamamoto   +2 more
doaj   +1 more source

One Single Nucleotide Polymorphism of the TRPM2 Channel Gene Identified as a Risk Factor in Bipolar Disorder Associates with Autism Spectrum Disorder in a Japanese Population

Diseases, 2020
The transient receptor potential melastatin 2 (TRPM2) is a non-specific cation channel, resulting in Ca2+ influx at warm temperatures from 34 °C to 47 °C, thus including the body temperature range in mammals.
Naila Al Mahmuda, Shigeru Yokoyama, Toshio Munesue, Kenshi Hayashi, Kunimasa Yagi, Chiharu Tsuji, Haruhiro Higashida   +6 more
doaj   +1 more source

Virtual Dwelling and the Phenomenology of Experience: Museum Encounters between Self and World

Humanities, 2023
This article provides an anthropologically derived philosophy of the nature of experience in relation to the lifeworld of virtual tourism. Framed around Martin Heidegger and Tim Ingold’s concept of dwelling, I interrogate what the implications of a ...
Catherine Palmer
doaj   +1 more source

Evidence for superior encoding of detailed visual memories in deaf signers

Scientific Reports, 2022
Recent evidence shows that deaf signers outperform hearing non-signers in some tests of visual attention and discrimination. Furthermore, they can retain visual information better over short periods, i.e., seconds. However, it is unknown if deaf signers’
Michael Craig, Michaela Dewar, Graham Turner, Trudi Collier, Narinder Kapur   +4 more
doaj   +1 more source

Impact des transitions urbaine et numérique sur la représentation des lieux

Développement Durable et Territoires, 2021
NUMCES research (Digital and creation of urban spaces) raises the question of the effect of urban and digital transition on the relationship between individuals and their living spaces.
Dorothée Marchand, Émeline Bailly, Aimée Casal, Pierre Dias   +3 more
doaj   +1 more source

Selegiline Ameliorates Depression-Like Behavior in Mice Lacking the CD157/BST1 Gene, a Risk Factor for Parkinson’s Disease

Frontiers in Behavioral Neuroscience, 2017
Parkinson’s disease (PD), a neurodegenerative disorder, is accompanied by various non-motor symptoms including depression and anxiety, which may precede the onset of motor symptoms. Selegiline is an irreversible monoamine oxidase-B (MAO-B) inhibitor, and
Satoka Kasai, Satoka Kasai, Toru Yoshihara, Toru Yoshihara, Olga Lopatina, Katsuhiko Ishihara, Haruhiro Higashida   +6 more
doaj   +1 more source