Results 181 to 190 of about 581,686 (314)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Cultural Values Model of <i>Pakikipag-ugnayan:</i> Examining <i>Hiya, Pakikisama,</i> and <i>Pakikipag-ugnayan</i> among Filipino Generation Z Nurses. [PDF]

Acta Med Philipp
Avila AB, Aldaba FOM, Almonte MLT, Alzate EB, Amita TB, Avila AM, Asoy ZJA, Cruz TJCD.   +7 more
europepmc   +1 more source

The Influencing Role of Cultural Values on Attitudes of the Chinese Public Towards Traditional Chinese Medicine (TCM) for the Control of COVID-19. [PDF]

Patient Prefer Adherence, 2023
Zhao H, Zhang R, Chen Y.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The influence of cultural identity on willingness to pay values in contingent valuation surveys

Current New Zealand resource management legislation requires local government actively recognise and take into account Māori values in resource management planning.
Awatere, Shaun
core  

Organizational cultural values and social capital in enhancing COVID-19 response capacity of community health centres in Zhejiang, China: a structural equation modelling study. [PDF]

BMC Health Serv Res
Zhou X, Tang J, Yang J, Zhou Z, Zhu H, Sun T, Huang X, Xu Y.   +7 more
europepmc   +1 more source

The impact of pandemic mental cognition on cultural values: an empirical study based on social media. [PDF]

BMC Public Health, 2023
Mo L, Liu Y, Li A, Liu T, Zhu T.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

What values best distinguish the world's cultures? The machine learning-based cultural values inventory. [PDF]

PNAS Nexus
Sheetal A, Madan S, Lee RL, Savani K.
europepmc   +1 more source

What cultural values determine student self-efficacy? An empirical study for 42 countries and economies. [PDF]

Front Psychol, 2023
Jin R, Wu R, Xia Y, Zhao M.
europepmc   +1 more source