Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Investigation of individual cultural values and perceived gender role on disaster management in Generation Z earthquake victims. [PDF]
Front PsycholAkkaş I +3 more
europepmc +1 more source
Ethnic pride and cultural values promote positive youth development in a conceptual replication of the Five Cs model. [PDF]
Dev Psychol, 2023 Johnson LE +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Cross-cultural perspectives on social difficulties and anxiety in youth: the role of family cultural values in Mexico and Italy. [PDF]
Front PsycholGalán-Vera IZ +3 more
europepmc +1 more source
The Influencing Role of Cultural Values on Attitudes of the Chinese Public Towards Traditional Chinese Medicine (TCM) for the Control of COVID-19. [PDF]
Patient Prefer Adherence, 2023 Zhao H, Zhang R, Chen Y.
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Organizational cultural values and social capital in enhancing COVID-19 response capacity of community health centres in Zhejiang, China: a structural equation modelling study. [PDF]
BMC Health Serv ResZhou X +7 more
europepmc +1 more source
The impact of pandemic mental cognition on cultural values: an empirical study based on social media. [PDF]
BMC Public Health, 2023 Mo L, Liu Y, Li A, Liu T, Zhu T.
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source