Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Ludic literacies at the intersections of cultures: an interview with James Paul Gee [PDF]
, 2008 Professor James Gee addresses issues of linguistics, literacies and cultures. Gee emphasises the importance of Discourses, and argues that the future of literacy studies lies in the interrogation of new media and the globalisation of ...
Phipps, A., St Clair, R.
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Building brands and fan relationships through social media : the case of the Grand Slam tennis events : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Sport and Exercise at Massey University, Palmerston North, New Zealand [PDF]
, 2016 Social media have become pervasive parts of society and modern consumer culture. However, sports scholars have noted a distinct lack of knowledge and understanding related to their use among sports properties.
Thompson, Ashleigh-Jane
core
Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei [PDF]
, 2013 n vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to make them more biologically relevant or to optimize growth is traditionally a laborious task.
Alsford +58 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Social Media and Consumer Culture: Addicted to the Idealized Consumer [PDF]
, 2018 For better or for worse, social media has become party of the fabric of society. As technology and social networking sites increasingly affect the behavior and culture around us, signs of digital addiction are on the rise.
Laeder, James
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Slow Religion: Literary Journalism as a Tool for Interreligious Dialogue
Religions, 2019 Intercultural and interfaith dialogue is one of the challenges faced by society. In a world marked by globalisation, digitisation, and migratory movements, the media is the agora for people of different faiths and beliefs.
Alba Sabaté Gauxachs +2 more
doaj +1 more source