Results 101 to 110 of about 3,626,823 (307)

Teensites.com: A Field Guide to the New Digital Landscape [PDF]

, 2001
A 2001 report from the Center for Media Education, provided here as background to work produced by Kathryn Montgomery after coming to American University and CSM (see http://www.centerforsocialmedia.org/resources/publications/ecitizens/index2.htm ...
Kathryn Montgomery
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Postcolonial Intellectuals: Exploring Belonging Across Borders in Igiaba Scego’s La mia casa è dove sono (My Home Is Where I Am)

Social Sciences
This article focuses on the life writing narratives of diasporic writers in Europe, such as the Italian writer of Somali descent Igiaba Scego, who, through her writing and public role, manages to create powerful interventions on issues of belonging ...
Sandra Ponzanesi, Maria Auxiliadora Castillo Soto   +1 more
doaj   +1 more source

Using ‘sport in the community schemes’ to tackle crime and drug use among young people: Some policy issues and problems [PDF]

, 2004
This is a PDF version of an article published in European physical education review © Sage, 2004. The definitive version is available at www.sagepub.com.This article discusses the effectiveness of sport in the community schemes such as the Positive ...
Andy Smith, Coalter, F., Coalter, F., Condon, J., Davis, G., Department of Culture, Media and Sport, Department of Culture, Media and Sport, Department of Culture, Media and Sport/Strategy Unit, DIVERT Trust, Elias, N., Gratton, C., Home Office, Hoover, N., Ivan Waddington, Long, J., Long, J., McCormack, F., Measham, F., Nichols, G., Parker, H., Ramella, M., Robins, D., Sport England, Sport England, Taylor, P., Tsuchiya, M., Waddington, I.   +26 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The internationalization of the media: Does local values and cultures undermined? [PDF]

, 2004
The mixture of culture exists in this world as the effect of global media and the emergence of new technologies. Media plays an important role in displaying the good and the bad to the audience.
Abdul Hamid, Norsiah
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Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

These are the echoes: Sound Proof 2008-2012 [PDF]

, 2013
Article in peer-reviewed journal Culture/Kultura for their thematic issue, Art Media and Cultural Memory.
Biagioli, Monica
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source