Results 111 to 120 of about 22,966,310 (260)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Culture and economy in the age of social media
, 2015 Understanding social media requires us to engage with the individual and collective meanings that diverse stakeholders and participants give to platforms. It also requires us to analyse how social media companies try to make profits, how and which labour
Fuchs, Christian
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Social SciencesThis article focuses on the life writing narratives of diasporic writers in Europe, such as the Italian writer of Somali descent Igiaba Scego, who, through her writing and public role, manages to create powerful interventions on issues of belonging ...
Sandra Ponzanesi +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Distinctions in the media welfare state: audience fragmentation in post-egalitarian Sweden
, 2017 This study draws on Pierre Bourdieu’s sociology of culture in order to shed new light on the ongoing fragmentation of media audiences and users. We use a multiple correspondence analysis on national survey data (n = 1604) collected in Sweden in 2015–2016
Johan Lindell +3 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
The Digital Switchover of Doordarshan: Intriguing Dynamics of Policy Options
Medijske Studije, 2015 In a country with few channels occupying the terrestrial space – all of which are owned by the public broadcaster – what is the rationale behind the expensive and mandatory transition to digital terrestrial television?
Vibodh Parthasarathi, Supriya Chotani
doaj
"High Culture as Entertainment" : Hybrid Reading Practices in a Live Book Club
, 2016 The Bushwick Book Club (BBC) is a live book club in which invited pop musicians perform musical interpretations of a predetermined literary work in a nightclub environment.
Persson, Magnus
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source