Results 111 to 120 of about 1,312,471 (266)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The funding of the BBC Government response to the third report from the Culture, Media and Sport Committee, Session 1999-2000 [PDF]
, 2000 Presented to Parliament by the Secretary of State for Culture, Media and Sport March 2000Available from British Library Document Supply Centre-DSC:OP-CM/4674 / BLDSC - British Library Document Supply CentreSIGLEGBUnited ...
Department for Culture, Media and Sport, London (United Kingdom)
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Pretend that it is real!: Convergence Culture in Practice [PDF]
, 2011 Media convergence has mainly been defined and explained as a technological and industrial phenomenon; as the process where new technologies are accommodated by existing media and communication industries and their cultures of production.
Denward, Marie
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The Digital Switchover of Doordarshan: Intriguing Dynamics of Policy Options
Medijske Studije, 2015 In a country with few channels occupying the terrestrial space – all of which are owned by the public broadcaster – what is the rationale behind the expensive and mandatory transition to digital terrestrial television?
Vibodh Parthasarathi, Supriya Chotani
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The use of video games and issues of aggressive behavior among pre-adolescent students
Ψυχολογία: το Περιοδικό της Ελληνικής Ψυχολογικής ΕταιρείαςThe aim of this research is to investigate the relationship between the use of video games and aggressive behavior among students of the fifth and the sixth grade of primary school. The sample consisted of 225 students.
Μαρία Τζιβάνη +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source