Results 81 to 90 of about 1,450,054 (334)

Microgravity-induced apoptosis in cultured glial cells

open access: yesEuropean Journal of Histochemistry, 2010
Apoptosis is a form of naturally occurring cell death that plays fundamental roles during embryonic developement. In adults, it neatly disposes of cells damaged by injuries provoked by external causes such as UV radiation, ionisation and heat shock ...
BM Uva   +6 more
doaj   +1 more source

A model of dissociated cortical tissue [PDF]

open access: yesProc. 7th Int. Workshop on Neural Coding, Montevideo, Uruguay, Nov. 7-12, 2007, pp. 24-27, 2008
A powerful experimental approach for investigating computation in networks of biological neurons is the use of cultured dissociated cortical cells grown into networks on a multi-electrode array. Such preparations allow investigation of network development, activity, plasticity, responses to stimuli, and the effects of pharmacological agents.
arxiv  

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale   +9 more
wiley   +1 more source

In vitro study on the mechanisms of action of a novel phytotherapeutic compound against human hepatoma cells

open access: yesAnnals of Hepatology, 2007
HepG2 human hepatoma cells were incubated for 24 or 48 h with various concentrations of YHK solution. After 24 h incubation, cell proliferation and cytotoxicity were determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl ...
Francesco Marotta   +5 more
doaj  

Evaluation of the Genotoxicity of Endodontic Materials for Deciduous Teeth Using the Comet Assay

open access: yesPesquisa Brasileira em Odontopediatria e Clínica Integrada, 2021
Objective: To evaluate genotoxicity of zinc oxide, P. A. calcium hydroxide, mineral trioxide aggregate and an iodoform paste using comet assay on human lymphocytes.
Nilton Cesar Nogueira dos Santos   +7 more
doaj  

Artificial intelligence and machine learning applications for cultured meat [PDF]

open access: yes
Cultured meat has the potential to provide a complementary meat industry with reduced environmental, ethical, and health impacts. However, major technological challenges remain which require time- and resource-intensive research and development efforts.
arxiv   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

Extraction and purification of tumorigenic Schwann cells in vitro from neurofibromatosis type 2 tissues

open access: yesChinese Journal of Contemporary Neurology and Neurosurgery, 2011
Objective To establish a simple method to extract and purify tumorigenic Schwann cells (TSCs) from neurofibromatosis type 2 (NF2) tumor tissues in vitro, in order to improve the successful rate of primary culture and obtain a large number of TSCs from ...
Wei WANG   +7 more
doaj  

Novel design of biplanar electrodes in a multiwell plate for transepithelial electrical resistance measurement in 3D cell cultures [PDF]

open access: yesVolume 387, 1 June 2025, 116413
Recent advances in microphysiological systems have underscored the need for novel sensing and monitoring systems specifically designed for three-dimensional (3D) cell culture. In this article, an original architecture of a cell-culture multiwell plate embedding an impedance spectroscopy monitoring system is presented alongside a fast and ...
arxiv   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

open access: yesMolecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam   +2 more
wiley   +1 more source

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