Results 91 to 100 of about 233,302 (259)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
ANALYSIS OF NONLINEAR CUMULATIVE DAMAGE MODEL CONSIDERING STRENGTH DEGRADATION
Jixie qiangdu, 2020 Fatigue damage accumulation and strength degradation occur simultaneously and interact with each other during service of engineering structures. In order to establish an improved Corten-Dolan cumulative damage model that takes the effects of strength ...
LI Wei
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
工程科学与技术The compression process of filled jointed rock under dry-wet cycles exhibits a distinct initial compaction stage; however, existing rock damage models rarely account for the filling characteristics of joints, making it difficult to accurately describe ...
CHAI Shaobo +6 more
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Probabilistic Cumulative Damage Analysis of Aluminum Light Pole Handholes
Journal of Experimental and Theoretical AnalysesAluminum light poles are essential components of modern infrastructure, providing illumination for highways, urban areas, and pedestrian pathways. Despite their importance, structural vulnerabilities in handholes—necessary for electrical access—can ...
Cameron Rusnak +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Results in EngineeringLong-term cumulative fatigue damage of mooring lines is crucial for the design of floating wind turbine structures (FWTs). Although many efforts are carried out for the offshore floating platforms, there still needs to be an efficient approach for ...
Chao Ren +2 more
doaj +1 more source