Results 71 to 80 of about 233,302 (259)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Cumulative damage for multi-type epidemics and an application to infectious diseases. [PDF]

J Math Biol, 2023
Fierro R, Fierro R.
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Effects of running distance on per-step and cumulative lower-extremity loading during a simulated treadmill half marathon

Frontiers in Public Health
BackgroundThe cumulative damage impulses have been proposed as a crucial parameter for analyzing joint kinetics and tissue loading during prolonged running.
Wenjing Quan, Huiyu Zhou, Yiwen Ma, Datao Xu, Zixiang Gao, Xuting Wang, Zsolt Radak, Yaodong Gu   +7 more
doaj   +1 more source

Numerical study of the relation between chosen statistical parameters of input stresses and cumulative fatigue damage provided rainflow decomposition

MATEC Web of Conferences, 2019
The aim of the article is to present a series of numerical tests of the cumulative fatigue damage solution under assumption of random stress input.
Sága Milan, Štalmach Ondrej, Blatnická Mária, Handrik Marian, Ságová Zuzana   +4 more
doaj   +1 more source

Experimental Investigation of Cumulative Damage and Self-Healing Properties of Smart Cementitious Composite under Continuous Compression Load. [PDF]

Materials (Basel), 2023
Chen W, Han C, Liu Y, Feng K, Zhuang S.
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Significance of damage index in prediction of systemic lupus erythematosus outcome

Терапевтический архив, 2003
Aim. To determine the significance of the damage index (SLICC/ACR DI) in the prognosis of the outcome of systemic lupus erythematosus (SLE). Materials and methods.
I A Tarasova, M M Ivanova, A P Zhornyak, V A Nasonova   +3 more
doaj  

A Nonlinear Viscoelastic Constitutive Model for Solid Propellant with Rate-Dependent Cumulative Damage. [PDF]

Materials (Basel), 2022
Chen S, Wang C, Zhang K, Lu X, Li Q.
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source