Results 61 to 70 of about 233,302 (259)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Continuum Theory of Cumulative Damage
Transactions of the Japan Society of Mechanical Engineers, 1976 A continuum theory of cumulative damage of materials which contain various types of distributed defects is proposed. At first, a study is made of general kinetic models representing three types of defect growth in the elastic material. Here it is assumed that the mechanism of such defect growth is governed by a kind of pure birth process.
openaire +4 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Construction of S-N curve evaluation model based on entropy for welded joints
Hanjie xuebaoThe S-N curve slope of the welded joints is substantially different from that of the conventional base material. Based on the definition of entropy in physics and thermodynamics, a S-N curve prediction model was introduced.
Wei WEI +4 more
doaj +1 more source
Experimental Study on the Seismic Behavior of Concrete Columns with 630 MPa High-Strength Stirrups
BuildingsThe widespread adoption of high-strength steel reinforcement in China has driven a growing demand for 600 MPa grade and higher-strength stirrups in engineering applications.
Mei-Ling Zhuang +6 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
BIRIKIMLI HASAR TEORILERI VE HAREKET ILETIM ELEMANINA UYGULANMASI
Havacılık ve Uzay Teknolojileri Dergisi, 2003 The prediction of fatigue failure in the materials has great importance in preventing of fatigue cracks. The most important thing in fatigue topic is the cumulative damage that can be seen in the materials subjected to ...
Gökhan Erkin Saatçi, Necati Tahralı
doaj
EnergiesElectrical insulation systems (EISs) are the principal reliability bottleneck of modern electrical machines (EMs). Among the many stresses acting on insulation, thermal stress is the most pervasive because it accelerates chemical reactions that ...
Antonis Theofanous +7 more
doaj +1 more source