Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Modeling Cyclic Crack Propagation in Concrete Using the Scaled Boundary Finite Element Method Coupled with the Cumulative Damage-Plasticity Constitutive Law. [PDF]
Materials (Basel), 2023 Alrayes O, Könke C, Ooi ET, Hamdia KM.
europepmc +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
BİRİKİMLİ HASAR TEORİLERİ VE YORULMA ÇATLAĞINA GÖRE ÖMÜR DEĞERLENDİRMELERİ
Havacılık ve Uzay Teknolojileri Dergisi, 2003 As known before, obtaining Woehler diagrams of the materials are very difficult. But to predict the service life of machine elements that are subject to cyclic loads, the cumulative damage theories are needed, and to use the teories maximum life values ...
Gökhan Erkin Saatçı , Necati Tahralı
doaj
Modelling Cumulative Seismic Damage at the Urban Scale
EntropyThe analysis of earthquake-induced damage scenarios at the urban scale is a fundamental tool for seismic risk assessment and mitigation and the management of urbanized areas exposed to seismic hazards.
Rosa Maria Sava +3 more
doaj +1 more source
The effect of smoking on cumulative damage in systemic lupus erythematosus: An incident cohort study. [PDF]
Lupus, 2021 McKown T +5 more
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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Cumulative damage effect of jaundice may be an effective predictor of complications in patients undergoing radical resection of Bismuth type II or above hilar cholangiocarcinoma. [PDF]
Ann Transl Med, 2021 Luo L +7 more
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source