Results 81 to 90 of about 1,180,431 (244)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Correlator Bank Detection of GW chirps. False-Alarm Probability, Template Density and Thresholds: Behind and Beyond the Minimal-Match Issue

, 2004
The general problem of computing the false-alarm rate vs. detection-threshold relationship for a bank of correlators is addressed, in the context of maximum-likelihood detection of gravitational waves, with specific reference to chirps from coalescing ...
A. N. Shirayev, A. P. Prudnikov, B. Lévine, C. W. Helström, E. Castillo, E. J. Gumbel, I. M. Pinto, J. Galambos, J. Galambos, K. J. Worsley, L. Pitt, L. E. Chernov, M. Abramowitz, M. Longo, R. P. Croce, R. J. Adler, S. Marano, S. O. Rice, Th. Demma, V. Matta, V. Pierro, V. I. Arnold, V. I. Bogachev   +22 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Recursive Numerical Evaluation of the Cumulative Bivariate Normal Distribution

Journal of Statistical Software, 2013
We propose an algorithm for evaluation of the cumulative bivariate normal distribution, building upon Marsaglia's ideas for evaluation of the cumulative univariate normal distribution.
Christian Meyer
doaj  

ON THE CUMULATIVE DISTRIBUTION FUNCTION OF THE VARIANCE-GAMMA DISTRIBUTION

Bulletin of the Australian Mathematical Society
AbstractWe obtain exact formulas for the cumulative distribution function of the variance-gamma distribution, as infinite series involving the modified Bessel function of the second kind and the modified Lommel function of the first kind. From these formulas, we deduce exact formulas for the cumulative distribution function of the product of two ...
openaire   +4 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dynamic effects of deep-hole cumulative blasting in coal seam and its application

工程科学学报, 2016
A model of cumulative blasting was established to study the mechanism of crack propagation and permeability increasing under cumulative blasting in a coal seam.
GUO De-yong, ZHAO Jie-chao, LÜ Peng-fei, ZHAI Min   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Improving environmental exposure analysis using cumulative distribution functions and individual geocoding

International Journal of Health Geographics, 2006
Background Assessments of environmental exposure and health risks that utilize Geographic Information Systems (GIS) often make simplifying assumptions when using: (a) one or more discrete buffer distances to define the spatial extent of impacted regions,
Chakraborty Jayajit, Zandbergen Paul A
doaj   +1 more source